53250-16-1Relevant academic research and scientific papers
Total synthesis of dictyodendrillin-B
Gerlach,Hoffmann
, p. 682 - 684 (1998)
Dictyodendrillin-B (1), an oxygenated sesquiterpene of marine origin, as well as its methoxyacetal 2 have been prepared by a concise route (6 steps, 43% overall yield).
Synthesis of Islatravir Enabled by a Catalytic, Enantioselective Alkynylation of a Ketone
Andreani, Teresa,Brunskill, Andrew,Fryszkowska, Anna,Huffman, Mark A.,Lévesque, Fran?ois,Li, Hongming,Maloney, Kevin M.,Mclaughlin, Mark,Nawrat, Christopher C.,Patel, Niki R.,Tschaen, David M.,Whittaker, Aaron M.,Xu, Yingju,Yang, Hao
supporting information, (2020/06/25)
The synthesis of the potent anti-HIV investigational treatment islatravir is described. The key step in this synthesis is a highly enantioselective catalytic asymmetric alkynylation of a ketone. This reaction is a rare example of the asymmetric addition o
