53250-84-3

Usage

Uses

Used in Pharmaceutical Industry:
Benzoic acid, 4-(aminosulfonyl)-2-chloro-, is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a key component in the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
This chemical compound is also utilized in the production of agrochemicals, such as pesticides and herbicides. Its antimicrobial properties make it a valuable ingredient in these products, helping to protect crops from diseases and pests.
Used in Food and Cosmetic Industry:
Benzoic acid, 4-(aminosulfonyl)-2-chloro-, is known for its preservative qualities and is often used in food and cosmetic products to prevent spoilage and extend shelf life. Its ability to inhibit the growth of bacteria, fungi, and mold makes it an effective preservative in a wide range of applications.
Used in Dyes and Pigments Industry:
This chemical is also employed in the manufacturing of dyes and pigments. Its unique chemical properties allow it to be used in the production of various colorants, contributing to the vibrancy and stability of these products.
Used in Organic Synthesis:
Benzoic acid, 4-(aminosulfonyl)-2-chloro-, is a versatile building block in organic synthesis. It can be used to synthesize a variety of other organic compounds, making it an important chemical in the field of organic chemistry.

Upstream product

• 42413-03-6 3-chloro-4-methylbenzenesulfonyl chloride 
• 46004-37-9 methyl 4-amino-2-chlorobenzoate 
• 260968-87-4 methyl 2-chloro-4-(chlorosulfonyl)benzoate 
• 51896-27-6 3-chloro-4-methylbenzenesulfonamide 

Downstream Products

• 1093254-19-3 4-(aminosulfonyl)-2-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]phenyl}methyl)benzamide trifluoroacetate 
• 1093254-30-8 4-(aminosulfonyl)-2-chloro-N-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)benzamide 

Relevant academic research and scientific papers

Second generation 2-pyridyl biphenyl amide inhibitors of the hedgehog pathway

Potent and efficacious inhibitors of the hedgehog pathway for the treatment of cancer have been prepared using the 2-pyridyl biphenyl amide scaffold common to the clinical lead GDC-0449. Analogs with polar groups in the para-position of the aryl amide ring optimized potency, had minimal CYP inhibition, and possessed good exposure in rats. Compounds 9d and 14f potently inhibited hedgehog signaling as measured by Gli1 mRNA and were found to be equivalent or more potent than GDC-0449, respectively, when studied in a Ptch+/- medulloblastoma allograft model, that is, highly dependent on hedgehog signaling.

PYRIDYL INHIBITORS OF HEDGEHOG SIGNALLING

The invention provides novel inhibitors of hedgehog signaling that are useful as s therapeutic agent for treating malignancies where the compounds have the general formula (I): where A, X, Y R1, R2, R3, R4, m and n are as described herein.

Pyridyl inhibitors of hedgehog signalling

The invention provides novel inhibitors of hedgehog signaling that are useful as a therapeutic agents for treating malignancies where the compounds have the general formula I: wherein A, X, Y R1, R2, R3, R4, m and n are as described herein.

AMINOSULPHONYL- OR AMINOSULPHONYLAMINO-SUBSTITUTED PHENYL ESTERS AS ESTRIOL AND ESTETROL PRODRUGS

The invention relates to estriol and estetrol prodrugs of general formula (I), in which group Y is bonded to the steroid, the method for production thereof, pharmaceutical compositions comprising said compounds and the use thereof for production of medicaments with estrogenic effect.

STEROID PRODRUGS WITH ANDROGENIC EFFECT

The invention relates to steroid prodrugs with androgenic effect of general formula (I), in which the group Z is bonded to the steroid, pharmaceutical compositions comprising said compounds and the use thereof for the production of medicaments with androgenic effect.

AMINOSULPHONYL- OR AMINOSULPHONYLAMINO-SUBSTITUTED PHENYL ESTERS AS ESTRADIOL PRODRUGS

The invention relates to estradiol prodrugs of general formula (I), in which the group Z is bonded to the steroid. The invention further relates to methods for production thereof, pharamceutical compositions comprising said compounds and use thereof for the production of medicaments with an estrogenic effect.

Estriol and estetrol prodrugs

This invention provides estriol and estetrol prodrugs of general formula (I), in which group Y is bonded to the steroid process for their production, pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutical agents with estrogenic action.

Steroid prodrugs with androgenic action

This invention relates to steroid prodrugs with androgenic action of general formula (I), in which group Z is bonded to the steroid, pharmaceutical compositions that contain these compounds as well as their use for the production of pharmaceutical agents with androgenic action.

Estradiol prodrugs

The invention relates to estradiol prodrugs of general formula (I), in which group Z is bonded to the steroid, process for their production, pharmaceutical compositions that contain these compounds, as well as their use for the production of pharmaceutica