5326-81-8

Upstream product

• 111-26-2 hexan-1-amine 
• 79-04-9 chloroacetyl chloride 

Downstream Products

• 100527-99-9 piperidino-acetic acid hexylamide 
• 5345-63-1 N-(iodoacetyl)-n-hexylamine 
• 306316-34-7 C₁₄H₁₉Cl₂NO₂ 
• 1228760-55-1 C₁₄H₁₉BrClNO₂ 
• 1228760-57-3 C₁₄H₁₉ClFNO₂ 
• 1214193-01-7 2-(2,6-dichlorophenylthio)-N-hexylacetamide 
• 1214193-19-7 2-(2,3-dichlorophenylthio)-N-hexylacetamide 
• 1214193-12-0 2-(2,4-dichlorophenylthio)-N-hexylacetamide 
• 1214193-06-2 2-(2,5-dichlorophenylthio)-N-hexylacetamide 

Relevant academic research and scientific papers

New interlocked molecules generated from a podand containing urea units and imidazolium salts using an anion template

A podand containing urea units (L) was found to form interlocked structures with 2,5-dihexylamide imidazolium salts (3·X), 2,5-dihexyl imidazolium salts (4·X), and 2,5-dihexyl benzoimidazolium salts (5·X), where X=Cl-, Br-, and PF6 - using anions as templates. The binding ability of L and guest molecules was evaluated by 1H NMR titrations in CDCl3. It was found that L could form complexes with guest molecules in the following order, 3·X>5·X>4·X. Stabilities of the complexes also depended on shape of the templated anions: Cl->Br -?PF6-. Hydrogen bonding and π-π stacking interactions played an important role in the self-assembling of these interlocked molecules.

Pyrimidine derivative multifunctional lubricating oil additive as well as preparation method and application thereof

The invention discloses a pyrimidine derivative multifunctional lubricating oil additive as well as a preparation method and application thereof. The preparation method of the pyrimidine derivative multifunctional lubricating oil additive comprises the following steps: firstly, enabling alkylamine and chloroacetyl chloride to be subjected to amidation reaction to obtain alkyl chloroacetyl chloride; then taking 4,6-dimethyl-2-mercaptopyrimidine to react with carbon disulfide and the alkyl chloroacetyl chloride, so as to obtain the pyrimidine derivative multifunctional lubricating oil additive with a general formula I. The pyrimidine derivative multifunctional lubricating oil additive disclosed by the invention has the characteristics of simple preparation method, moderate technological conditions, easiness for obtaining raw materials, low synthesis cost, high synthesis yield and the like, and can be used as an extreme-pressure, wear-resisting, friction-reduction and anticorrosion additive of lubricating oil; the bearing capability of base oil can be remarkably improved and the wear-resisting and friction-reduction performance is improved, so that the pyrimidine derivative multifunctional lubricating oil additive is an environment-friendly multifunctional lubricating oil additive. The formula I is shown in the description.

2,5-dialkylacetamide-1,3,4-thiadiazole for biodegradable lubricating oil additives, and preparation method thereof

The invention discloses 2,5-dialkylacetamide-1,3,4-thiadiazole for biodegradable lubricating oil additives, and a preparation method thereof, wherein the structure of the 2,5-dialkylacetamide-1,3,4-thiadiazole is represented by a formula (1), R is a C1-C30 linear chain or branched chain alkyl group, 2,5-dimercapto-1,3,4-thiadiazole, n-butylamine, dodecylamine and chloroacetyl chloride are adopted as raw materials, triethylamine is adopted as an acid binding agent, dichloromethane is adopted as a solvent, an intermediate alkyl chloroacetamide is firstly obtained, and then the target product is obtained. According to the present invention, the source of the used raw materials is sufficient, the price of the used raw materials is low, the prepared intermediate chloroacetamide uses triethylamine as the acid binding agent, the synthesis process condition is mild, the process route is simple, the yield is high, and the obtained product has excellent extreme pressure wear resistance, has the good biodegradation performance after the use, and is the environmentally friendly multifunctional lubricating oil additive.

Benzotriazole xanthate derivative lubricant additive and preparation method thereof

The invention discloses a benzotriazole xanthate derivative lubricant additive. According to the invention, the benzotriazole xanthate derivative lubricant additive is prepared according to the following steps: performing amidation on alkylamine and chloroacetyl chloride under the effect of alkali, thereby acquiring alkyl chloroacetamide; performing nucleophilic substitution reaction on benzotriazole, chloropropanol and carbon disulfide, thereby acquiring benzotriazole propyl xanthic sodium or potassium; performing nucleophilic substitution reaction on alkyl chloroacetamide and benzotriazole propyl xanthic sodium or potassium, thereby acquiring a compound with a general formula I. According to the invention, the preparation method is simple, the technical condition is mild, the raw materials are easily acquired, the compounding cost is low and the compounding yield is high. The benzotriazole xanthate derivative can be independently used as an extreme pressure wear-resistant anticorrosion additive of lubricating oil, also can be used together with the other lubricant additives, is capable of obviously promoting the carrying capacity of the base oil, greatly improving the wear-resistant antifriction performance of the base oil and effectively promoting the corrosion resistance of the base oil and is a biodegradable multifunctional lubricant additive.

Alkyl acetamidobenzotriazole derivative lubricating oil additive and preparation method thereof

The invention discloses a biodegradable alkyl acetamidobenzotriazole derivative lubricating oil additive which does not contain sulfur, phosphorus, halogens and metal elements as well as a preparation method and application thereof. The preparation method comprises the following steps: under the action of alkali, performing amidation on alkyl amine and chloroacetyl chloride to obtain alkyl chloroacetamide; and then performing a nucleophilic substitution reaction with benzotriazole to obtain a target compound of a formula I. The preparation method disclosed by the invention is simple in preparation method, mild in process condition, easily available in raw material, low in preparation cost and high in synthetic yield. The novel alkyl acetamidobenzotriazole derivative can be independently used as an extreme pressure anti-wear corrosion-resistant additive of lubricating oil, also can be used with other lubricating oil additives in a compound manner, also can be used in common working conditions and high-temperature working conditions, can improve the bearing capacity of basic oil obviously and improve the anti-wear performance, and is the lubricating oil additive which is environmentally friendly and multi-functional. The formula I is as shown in the specification.

Complexes of selected late period lanthanide(III) cations with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl ligands-A new platform for the development of paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents

A series of 18 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid amide (DOTAM)-alkyl derived complexes with selected late lanthanide(III) cations (Dy3+, Tb3+, and Tm3+) has been synthesized; their magnetic properties have been evaluated and compared to those derived from DOTAM. Peralkylation of cyclen with corresponding N-iodoacetyl amines was utilized as the key step in the synthesis. Chemical exchange saturation transfer (CEST) spectra of the complexes have been acquired at 37 C, revealing that Tm3+-derived DOTAM-alkyl complexes possess the most favorable properties as potential paramagnetic chemical exchange saturation transfer (PARACEST) magnetic resonance imaging (MRI) contrast agents.

Synthesis and in vitro antimicrobial activity of benzo[b][1,4]thiazin-3(4H) -ones via smiles rearrangement

New benzo[b][1,4]thiazin-3(4H)-one derivatives (compounds 12a-p) were synthesized via Smiles rearrangement and assayed in vitro for their antimicrobial activity against Gram-positive, Gram-negative bacteria and fungi. The antimicrobial activity of the benzo[b][1,4]thiazin-3(4H)-ones showed, on the whole, potent toward all tested Gram-positive and Gram-negative microorganism (minimal inhibitory concentration ranging from 16 to 64 lg/ml), whereas weak effectiveness was exhibited against fungi. Data obtained suggested that 12g, 12i, and 12o exerted the best antibacterial activity against Gram-positive bacteria and compound 12b demonstrated the best inhibition of Gram-negative bacteria. These observations provide some predictions to design further antimicrobial active compounds prior to their synthesis following with molecular modeling studies. Springer Science+Business Media, LLC 2010.

Synthesis of benzo[b][1,4]oxazin-3(4H)-ones via smiles rearrangement for antimicrobial activity

The benzo[b][1,4]oxazin-3(4H)-one derivatives, 1a-p, carrying F, Br, and Cl on the benzene ring, or benzyl, cyclohexyl, n-hexyl, and tetrafuryl methylene groups attached to nitrogen atom were synthesized via Smiles rearrangement and assayed in vitro for their antimicrobial activity against Gram-positive, Gram-negative bacteria, and fungi. The antimicrobial activity of the benzo[b][1,4]oxazin-3(4H)-ones showed, on the whole, potency toward all the tested Gram-positive and Gramnegative microorganism (MIC ranging from 16 to 64 lg/ ml), whereas weak effectiveness was exhibited against fungi. Data obtained suggest that fluorine atom in the compounds, 1c, 1f, 1i plays an important role in enhancing the antimicrobial properties of this class of compounds. These observations provide some predictions to design further antimicrobial active compounds prior to their synthesis according to molecular modeling studies.

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.

Modulating the development of E. coli biofilms with 2-aminoimidazoles

The synthesis of a 20 member 2-aminoimidazole/triazole pilot library is reported. Each member of the library was screened for its ability to inhibit or promote biofilm development of either Escherichia coli and Acinetobacter baumannii. From this screen, E. coli-selective 2-aminoimidazoles were discovered, with the best inhibitor inhibiting biofilm development with an IC50 of 13 μM. The most potent promoter of E. coli biofilm formation promoted biofilm development by 321% at 400 μM.