53273-26-0

Upstream product

• 4254-32-4 indan-2-carboxylic acid methyl ester 
• 756-79-6 dimethyl methane phosphonate 
• 81290-34-8 indan-2-carboxylic acid ethyl ester 
• 91-13-4 α,α'-dibromo-o-xylene 
• 83721-28-2 2-(ethoxycarbonyl)-2-(tert-butoxycarbonyl)indan 
• 83721-29-3 indan-2,2-dicarboxylic acid ethyl ester 
• 66014-45-7 diethyl indan-2,2-dicarboxylate 
• 2437-08-3 indane-2,2-dicarboxylic acid 
• 25177-85-9 2-indancarboxylic acid 

Downstream Products

• 53403-08-0 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-(R)-3-hydroxy-3-indan-2-yl-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 53273-46-4 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-(S)-3-hydroxy-3-indan-2-yl-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 
• 53273-41-9 Biphenyl-4-carboxylic acid (3aR,4R,5R,6aS)-4-((E)-3-indan-2-yl-3-oxo-propenyl)-2-oxo-hexahydro-cyclopenta[b]furan-5-yl ester 

Relevant academic research and scientific papers

A general procedure for the preparation of β-ketophosphonates

(Chemical Equation Presented) A mild, high-yielding procedure for the preparation of β-ketophosphonates is described. The condensation is general with respect to the ester and phosphonate, and the products are obtained in high yields within minutes at 0°C. The reaction procedure is operationally simple and amenable to large-scale preparations. 2009 American Chemical Society.

Synthesis and biological activity of novel carbacyclins having bicyclic substituents on the ω-chain

A number of carbacyclins having bicyclic substituents on the ω-chain have been synthesized and tested for antiplatelet aggregation activity in vitro (against collagen-induced aggregation of rat platelet), for reduction of systemic blood pressure in vivo (ability to reduce the blood pressure in anesthetized rat by iv injection), and for cytoprotective activity (protection against ethanol-induced rat gastric lesion). The most effective compound for each activity was [3aS-[2E,3aα,4α(3R),5β,6aα]]-5-[hexahydro-5-hydroxy-4-[3-hydroxy-3-(2- indanyl)-1-propynyl]-2(1H)-pentalenylidene]pentanoic acid (compound 11a), while some 1,4-benzodioxan analogues had selectivity for organ-protective activity, and indan analogues showed selectivity in their antiaggregation activity.

15-Substituted-ω-pentanorprostaglandins

The 15-substituted-ω-pentanorprostaglandins and various intermediates employed in their preparation. The novel prostaglandins of this invention have been found to have activity profiles comparable to the parent prostaglandins, but exhibit a greater tissue