4254-32-4

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxycarbonyl-indane, 98% is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to undergo esterification and reduction reactions. This allows for the creation of a wide range of compounds, including antidepressants and antipsychotic medications.
Used in Chemical Industry:
2-Methoxycarbonyl-indane, 98% is used as a versatile building block in organic synthesis for its high purity and ability to participate in various chemical reactions. This makes it suitable for use in research and manufacturing processes, contributing to the development of new compounds and materials.

Upstream product

• 67-56-1 methanol 
• 25177-85-9 2-indancarboxylic acid 
• 15219-34-8 Oxalyl bromide 
• 496-11-7 INDANE 
• 22955-77-7 methyl 1-indanone-2-carboxylate 
• 124-41-4 sodium methylate 
• 91-13-4 α,α'-dibromo-o-xylene 
• 77-76-9 2,2-dimethoxy-propane 
• 4744-10-9 dimethoxypropane 
• 108-59-8 malonic acid dimethyl ester 
• 74-88-4 methyl iodide 
• 201230-82-2 carbon monoxide 
• 6351-10-6 1-Indanol 
• 64-18-6 formic acid 

Downstream Products

• 175079-50-2 2-Carbamoylindane 
• 65057-07-0 5-Cinnamoyl-2-indancarbonsaeure-methylester 
• 65057-05-8 5-(4'-Fluor-benzoyl)-2-indancarbonsaeure-methylester 
• 65056-77-1 5-(3'-Chlor-benzoyl)-2-indancarbonsaeure 
• 65056-76-0 5-(4'-Methyl-benzoyl)-2-indancarbonsaeure 
• 65056-87-3 5-(4'-Phenyl-benzoyl)-2-indancarbonsaeure 
• 65057-04-7 5-(4'-Nitro-benzoyl)-2-indancarbonsaeure-methylester 
• 65056-79-3 5-(2'-Methyl-benzoyl)-2-indan-carbonsaeure 
• 65057-06-9 5-(2'.4'-Dichlor-benzoyl)-2-indancarbonsaeure-methylester 
• 65057-13-8 5-(4'-Amino-benzoyl)-2-indan-carbonsaeure-methylester 
• 65057-10-5 5-(2'.5'-Dichlor-benzoyl)-2-indancarbonsaeure-methylester 
• 65057-08-1 5-Cyclohexancarbonyl-2-indancarbonsaeure-methylester 
• 65057-26-3 5-Phenylacetyl-2-indancarbonsaeure-methylester 
• 65057-03-6 5-(3'-Methyl-benzoyl)-2-indancarbonsaeure-methylester 

Relevant academic research and scientific papers

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors

Novel therapies are required to treat chronic bacterial infections in cystic fibrosis (CF) sufferers. The most common pathogen responsible for these infections is Pseudomonas aeruginosa, which persists within the lungs of CF sufferers despite intensive antibiotic treatment. P. aeruginosa elastase (also known as LasB or pseudolysin) is a key virulence determinant that contributes to the pathogenesis and persistence of P. aeruginosa infections in CF patients. The crucial role of LasB in pseudomonal virulence makes it a good target for the development of an adjuvant drug for CF treatment. Herein we discuss the discovery of a new series of LasB inhibitors by virtual screening and computer assisted drug design (CADD) and their optimization leading to compounds 29 and 39 (Ki = 0.16 μM and 0.12 μM, respectively).

COMBINATION THERAPY

The invention provides a combinations and pharmaceutical compositions comprising (i) a compound which is an indane according to Formula (I) or a pharmaceutically acceptable salt thereof; and (ii) one or more CFTR modulator; wherein R1, R2

N-Atom Deletion in Nitrogen Heterocycles

Excising the nitrogen in secondary amines, and coupling the two residual fragments is a skeletal editing strategy that can be used to construct molecules with new skeletons, but which has been largely unexplored. Here we report a versatile method of N-atom excision from N-heterocycles. The process uses readily available N-heterocycles as substrates, and proceeds by N-sulfonylazidonation followed by the rearrangement of sulfamoyl azide intermediates, providing various cyclic products. Examples are provided of deletion of nitrogen from natural products, synthesis of chiral O-heterocycles from commercially available chiral β-amino alcohols, formal inert C?H functionalization through a sequence of N-directed C?H functionalization and N-atom deletion reactions in which the N-atom can serve as a traceless directing group.

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, n and p are as defined herein

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, M, ?, n, p, and q are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.

A general platinum-catalyzed alkoxycarbonylation of olefins

Hydroxy- and alkoxycarbonylation reactions constitute important industrial processes in homogeneous catalysis. Nowadays, palladium complexes constitute state-of-the-art catalysts for these transformations. Herein, we report the first efficient platinum-catalysed alkoxycarbonylations of olefins including sterically hindered and functionalized ones. This atom-efficient catalytic transformation provides straightforward access to a variety of valuable esters in good to excellent yields and often with high selectivities. In kinetic experiments the activities of Pd- and Pt-based catalysts were compared. Even at low catalyst loading, Pt shows high catalytic activity.

Cobalt(II)-Catalyzed Alkoxycarbonylation of Aliphatic Amines via C-N Bond Activation

The first cobalt-catalyzed deaminative alkoxycarbonylation reaction was described for the conversion of readily available primary alkyl amines to synthetically versatile esters with moderate to high yields. This transformation shows good functional group compatibility and can serve as a powerful tool for the modification of alkyl amine-containing complex natural products and drug molecules.

Palladium-catalyzed selective generation of CO from formic acid for carbonylation of alkenes

A general and selective palladium-catalyzed alkoxycarbonylation of all kinds of alkenes with formic acid (HCOOH, FA) is described. Terminal, di-, tri-, and tetra-substituted including functionalized olefins are converted into linear esters with high yields and regioselectivity. Key-to-success is the use of specific palladium catalysts containing ligands with built-in base, e.g., L5. Comparison experiments demonstrate that the active catalyst system not only facilitates isomerization and carbonylation of alkenes but also promotes the selective decomposition of HCOOH to CO under mild conditions.

Alkoxycarbonylation of olefins with carbon dioxide by a reusable heterobimetallic ruthenium-cobalt catalytic system

The heterobimetallic ruthenium-cobalt catalytic system exhibited good catalytic performance and reusability in the reductive alkoxycarbonylation of olefins with carbon dioxide. Compared to the previous system only consisting of ruthenium catalyst, the binary catalyst system effectively reduced the usage of noble metal and ionic liquid additives. The respective contribution of ruthenium and cobalt catalysts in this multiple-step catalytic process was investigated by a series of condition-controlled experiments. The evolution of the ruthenium catalyst and the occurrence of alkene hydrogenation during the reaction was explained by theortical calculations.

Development of efficient palladium catalysts for alkoxycarbonylation of alkenes

Herein, we report a general and efficient Pd-catalysed alkoxycarbonylation of sterically hindered and demanding olefins including a variety of tri-, tetra-substituted and 1,1-disubstituted alkenes. In the presence of 1,3-bis(tert-butyl(pyridin-2-yl)phosphanyl)propane L3 or 1,4-bis(tert-butyl(pyridin-2-yl)phosphanyl)butane L4 the desired esters are obtained in good yields and selectivities. Similar transformation is obtained using tertiary ether as showcased in the carbonylation of MTBE to the corresponding linear ester in high yield and selectivity.