4254-32-4

Basic information

• Product Name: 2-Methoxycarbonyl-indane, 98 %
• Synonyms: 2-Methoxycarbonyl-indane, 98 %;2-Methoxycarbonyl-indane;Methyl 2,3-dihydro-1H-indene-2-carboxylate;Methyl Indane-2-carboxylate
• CAS NO: 4254-32-4
• Molecular Formula: C₁₁H₁₂O₂
• Molecular Weight: 176.21
• Mol File: 4254-32-4.mol
• Article Data: 26

Chemical Properties

• Boiling Point: 83-84 °C(Press: 0.8 Torr)
• Appearance: /
• Density: 1.128±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-Methoxycarbonyl-indane, 98 %(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methoxycarbonyl-indane, 98 %(4254-32-4)
• EPA Substance Registry System: 2-Methoxycarbonyl-indane, 98 %(4254-32-4)

Safety Data

• Hazardous Substances Data: 4254-32-4(Hazardous Substances Data)

Usage

General Description

2-Methoxycarbonyl-indane, 98% is a chemical compound with the molecular formula C11H10O2. It is a 98% pure form of the compound, which is commonly used in the synthesis of various pharmaceuticals, including antidepressants and antipsychotic medications. It is an important intermediate in organic synthesis, and its high purity makes it suitable for use in research and manufacturing processes. The compound is known for its ability to undergo various chemical reactions, including esterification and reduction, making it a versatile building block for the creation of a wide range of compounds. Overall, 2-Methoxycarbonyl-indane, 98% is a valuable chemical for the pharmaceutical and chemical industries due to its purity and versatility in organic synthesis.

Upstream product

• 91-13-4 α,α'-dibromo-o-xylene 
• 105-53-3 diethyl malonate 
• 57060-86-3 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 
• 81290-34-8 indan-2-carboxylic acid ethyl ester 
• 67-56-1 methanol 
• 37414-44-1 indan-2-carbaldehyde 
• 2975-41-9 2,3-dihydro-1H-inden-2-amine 
• 201230-82-2 carbon monoxide 
• 124-38-9 carbon dioxide 
• 95-13-6 1-indene 
• 64-18-6 formic acid 
• 6351-10-6 1-Indanol 
• 25177-85-9 2-indancarboxylic acid 
• 74-88-4 methyl iodide 

Downstream Products

• 65056-87-3 5-(4'-Phenyl-benzoyl)-2-indancarbonsaeure 
• 65056-75-9 5-(4'-Chlor-benzoyl)-2-indancarbonsaeure 

Relevant articles and documents

Virtual Screening Approach to Identifying a Novel and Tractable Series of Pseudomonas aeruginosa Elastase Inhibitors

Novel therapies are required to treat chronic bacterial infections in cystic fibrosis (CF) sufferers. The most common pathogen responsible for these infections is Pseudomonas aeruginosa, which persists within the lungs of CF sufferers despite intensive antibiotic treatment. P. aeruginosa elastase (also known as LasB or pseudolysin) is a key virulence determinant that contributes to the pathogenesis and persistence of P. aeruginosa infections in CF patients. The crucial role of LasB in pseudomonal virulence makes it a good target for the development of an adjuvant drug for CF treatment. Herein we discuss the discovery of a new series of LasB inhibitors by virtual screening and computer assisted drug design (CADD) and their optimization leading to compounds 29 and 39 (Ki = 0.16 μM and 0.12 μM, respectively).

N-Atom Deletion in Nitrogen Heterocycles

Excising the nitrogen in secondary amines, and coupling the two residual fragments is a skeletal editing strategy that can be used to construct molecules with new skeletons, but which has been largely unexplored. Here we report a versatile method of N-atom excision from N-heterocycles. The process uses readily available N-heterocycles as substrates, and proceeds by N-sulfonylazidonation followed by the rearrangement of sulfamoyl azide intermediates, providing various cyclic products. Examples are provided of deletion of nitrogen from natural products, synthesis of chiral O-heterocycles from commercially available chiral β-amino alcohols, formal inert C?H functionalization through a sequence of N-directed C?H functionalization and N-atom deletion reactions in which the N-atom can serve as a traceless directing group.

INDANE DERIVATIVES FOR USE IN THE TREATMENT OF BACTERIAL INFECTION

The invention relates to a compound which is an indane according to Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, R6, L, M, ?, n, p, and q are as defined herein. The compounds are useful in the treatment of antibacterial infection either as stand alone antibiotics, or in combination with further antibiotics.