53278-17-4Relevant academic research and scientific papers
Prodrugs: Part 3. 2-Formylphenyl esters of indomethacin, ketoprofen and ibuprofen and 6-substituted 2-formyl and 2-acylphenyl esters of aspirin
Abordo, Evelyn A.,Bowden, Keith,Huntington, Anthony P.,Powell, Sarah L.
, p. 95 - 101 (2007/10/03)
The synthesis and study of a novel series of potential prodrugs of indomethacin, ketoprofen, ibuprofen and aspirin are reported. 2-Formylphenyl esters of the NSAIDs, together with two 6-substituted 2-formyl and two 2-acylphenyl aspirins and 4-formylphenyl indomethacin, have been prepared. A study of their alkaline and neutral hydrolysis shows that these compounds, with the exception of 2-acetylphenyl aspirin, act as true prodrugs of the NSAIDs, giving the NSAID and acylphenol. The rates of hydrolysis and activation parameters indicate that the 2-acylphenyl esters employ an intramolecular catalytic route. The 2-formylphenyl esters were more potent as anti-inflammatory agents than the parent compounds in the carragheenan-induced paw oedema test.
Base-Induced Chemiluminescence of Acetoxy-Substituted Benzofuran Dioxetanes by an Intramolecular Electron Transfer (CIEEL) Mechanism
Adam, Waldemar,Schulz, Manfred H.
, p. 2455 - 2462 (2007/10/02)
Tetraphenylporphine-sensitized photooxygenation of acetoxy-substituted benzofuran derivatives 2 afforded the corresponding benzofuran dioxetanes 3.The base-induced decomposition of these dioxetanes was studied and shown to involve an intramolecular CIEEL
