532926-51-5

Basic information

• Product Name: Pentanoic acid, 5-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]amino]-, phenylmethyl ester
• CAS NO: 532926-51-5
• Molecular Formula: C20H30N2O5
• Molecular Weight: 378.469
• Mol File: 532926-51-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pentanoic acid, 5-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]amino]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Pentanoic acid, 5-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]amino]-, phenylmethyl ester(532926-51-5)
• EPA Substance Registry System: Pentanoic acid, 5-[[(2S)-2-[[(1,1-dimethylethoxy)carbonyl]amino]-1-oxopropyl]amino]-, phenylmethyl ester(532926-51-5)

Safety Data

• Hazardous Substances Data: 532926-51-5(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 63649-14-9 δ-aminovaleric acid benzyl ester p-toluenesulfonate 

Relevant articles and documents

Synthesis and evaluation of new elastase substrates as tripartate prodrugs

Compounds consisting of a peptide sequence, 4-aminobutyric acid or 5-aminovaleric acid, respectively, as spacer units, and benzyl alcohol as a model leaving group have been prepared and tested for their ability to serve as substrates for porcine pancreatic elastase and human polymorphnuclear elastase. Those compounds containing an Ala-Ala-Ala sequence served as effective substrates for both enzymes. Hydrolytic cleavage, however, occurred exclusively at the ester bond, not at the peptide-spacer bond. In order to direct the cleavage site from the ester to the amide bond the peptide sequence was varied. We introduced a proline residue in P3 (in relation to the ester bond) which is known to prevent the cleavage of a substrate by elastase. No hydrolysis, however, either of the ester bond or of the peptide-spacer bond, was found for these compounds.