63649-14-9

Usage

Chemical Properties

White Solid

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 100-51-6 benzyl alcohol 
• 660-88-8 5-aminopentanoic acid 

Downstream Products

• 532926-51-5 benzyl N-BOC-alanyl-5-aminovaleriate 
• 63984-37-2 N-Iodacetyl-δ-aminovaleriansaeurebenzylester 
• 1173377-58-6 Nα-Nε-bis(hexadecanoyl)-N-[4-(benzyloxycarbonyl)butyl]-L-lysinamide 
• 63984-35-0 N-Iodacetyl-δ-aminovaleriansaeure 

Relevant academic research and scientific papers

DELIVERY OF TARGET SPECIFIC NUCLEASES

Described herein are lipid nanoparticles comprising cationic lipids and other lipids and also comprising engineered nucleases facilitate transfer of nucleic acids to cells.

LIPID DELIVERY OF THERAPEUTIC AGENTS TO ADIPOSE TISSUE

A method of treating a disease mediated by protein expression in adipose tissue by intraperitoneally administering a composition comprising a lipid nanoparticle encapsulating or associated with a therapeutic agent (e.g., a nucleic acid), thereby delivering the therapeutic agent to adipose tissue of the subject and altering protein expression in the adipose tissue is provided herein. A method for delivering a therapeutic agent to adipose tissue of a subject in need thereof is also provided.

Molecular structural requirements, dye specificity, and application of anionic peptide amphiphiles that induce intense fluorescence in cationic dyes

We have previously reported that a double-chain anionic amphiphile capable of intermolecular triple hydrogen bonds could form extremely hydrophobic sites in water and specifically incorporated stilbazolium-based compact hemicyanine dyes as monomeric species, resulting in induction of intense fluorescence emission in the dyes. In this paper, the structural requirements of the intense fluorescence-inducing amphiphiles were investigated. It is noted that the introduction of β-Ala residues into two long-chain alkyl group moieties was most effective for the amphiphiles derived from L-glutamic acid with relatively shorter side-chain methylenes. The dye specificity in terms of induction of the intense fluorescence was also investigated using hemicyanines (stilbazolium etc.), cyanine, carbocyanine, thiacarbocyanines, and azo dye. The amphiphile with the shortest octanoyl-β-alanyl double-chain alkyl groups, longer side-chain, and shorter spacer was found to show increased sensitivity to alkali metal ions, especially Li+. This could be a potential OFF-ON type fluorescence sensor for Li+. The Royal Society of Chemistry 2009.

Semisynthesis of RPR 121056A, a major metabolite of irinotecan (CPT-11)

The semisynthesis of RPR 121056A (4), a major metabolite of irinotecan (CPT-11, 2) is reported starting from SN-38 (3) and an appropriate side-chain precursor, and using a 2-step sequence. This semisynthesis is based on the 10-O-acylation of SN-38 with the conveniently protected carbamoylchloride derivative 10 followed by cleavage of the benzylic protecting groups by hydrogenolysis. Preliminary in vitro results show that RPR 121056A displays no cytotoxicity.

2 AND 3-SUBSTITUTED ENKEPHALINS

Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.