532986-41-7Relevant articles and documents
Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and their structure-activity relationships
Matsui, Toshiaki,Kondo, Takashi,Nishita, Yoshitaka,Itadani, Satoshi,Nakatani, Shingo,Omawari, Nagashige,Sakai, Masaru,Nakazawa, Shuichi,Ogata, Akihito,Mori, Hideaki,Terai, Kouichiro,Kamoshima, Wataru,Ohno, Hiroyuki,Obata, Takaaki,Nakai, Hisao,Toda, Masaaki
, p. 3757 - 3786 (2007/10/03)
Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α expression