532986-70-2Relevant academic research and scientific papers
Drugs containing phosphoric acid derivatives as the active ingredient
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, (2008/06/13)
The present invention relates to phosphoric acid derivatives represented by general formula (I), wherein each symbol is as defined in the description and nontoxic salts thereof. Because of having a TNFα production inhibitory effect, the compounds represented by general formula (I) are useful as preventives and/or remedies for rheumatoid arthritis, ulcerative colitis, Crohn's disease, hepatitis, sepsis, hemorrhagic shock, multiple sclerosis, cerebral infarction, diabetes, interstitial pneumonia, uveitis, pain, glomerulonephritis, HIV-associated diseases, cachexia, myocardial infarction, chronic heart failure, oral aphtha, Hansen's disease, infection, etc.
Highly potent inhibitors of TNF-α production. Part I: Discovery of new chemical leads and their structure-activity relationships
Matsui, Toshiaki,Kondo, Takashi,Nishita, Yoshitaka,Itadani, Satoshi,Nakatani, Shingo,Omawari, Nagashige,Sakai, Masaru,Nakazawa, Shuichi,Ogata, Akihito,Mori, Hideaki,Terai, Kouichiro,Kamoshima, Wataru,Ohno, Hiroyuki,Obata, Takaaki,Nakai, Hisao,Toda, Masaaki
, p. 3757 - 3786 (2007/10/03)
Discovery of new chemical leads of inhibitors for TNF-α production starting from the chemical modification of 1 is reported. Further biological studies of 1 to disclose the site of its action strongly suggested that 1 inhibits LPS-induced TNF-α expression
