53312-75-7

Upstream product

• 2447-79-2 2,4-dichlorobenzamide 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 50-84-0 2,4 dichlorobenzoic acid 
• 6574-98-7 2,4-dichlorobenzylnitrile 
• 1141894-65-6 C₇H₄Cl₂N₂O₃ 

Relevant academic research and scientific papers

Highly efficient Pd-catalyzed synthesis of nitriles from aldoximes

An expedient method of Pd-catalyzed conversion of aldoxime into nitrile was developed. The reaction was carried out under the influence of Pd(OAc)2/PPh3 in refluxing CH3CN to provide good to high yields. The use of Cs2CO3 (0.1-0.5 equiv) was crucial in some cases.

A 4, 6 - double-halogenated isophthalonitrile preparation method (by machine translation)

The present invention relates to the technical field of the synthesis of pharmaceutical intermediates, in particular to a 4, 6 - double-halogenated isophthalonitrile preparation method, through the use of cheap and easily obtained 2, 4 - double-halo benzoic acid as the raw material, the reaction of the halide, the amidation reaction, dehydration reaction, the nitration reaction, reduction reaction, the diazotization reaction, the substitution reaction for the synthesis of 4, 6 - double-halogenated isophthalonitrile; the total yield can be 21.5%. The process route is easily obtained and cheap materials, few by-products, the purification treatment is the process is simple, easy to realize industrial production. (by machine translation)