53312-90-6Relevant academic research and scientific papers
Palladium-Catalyzed Regioselective Direct Cyanation of Acetanilide Derivatives with K4[Fe(CN)6] by C–H Bond Activation
Kianmehr, Ebrahim,Faghih, Nasser,Tanbakouchian, Arezoo,Mahdavi, Mohammad
, p. 4269 - 4274 (2016/09/14)
A practical, versatile, and efficient method for the palladium-catalyzed direct cyanation of readily available acetanilides with K4[Fe(CN)6] as a safe cyanating agent through C–H bond activation with excellent C2 regioselectivity was developed. This finding represents a new strategy for the synthesis of N-(2-cyanoaryl)acetamides, which are important structural motifs in natural products and pharmaceuticals.
Copper-catalyzed oxidative ring closure of ortho-cyanoanilides with hypervalent iodonium salts: Arylation-ring closure approach to iminobenzoxazines
Aradi, Klra,Novk, Zoltn
supporting information, p. 371 - 376 (2015/03/05)
A novel, highly modular synthetic methodology with high functional group tolerance was developed for the construction of iminobenzoxazine derivatives from ortho-cyanoanilides and diaryliodonium triflates via an oxidative arylation-cyclization path. The reaction is supposed to involve the formation of highly active aryl-copper(III) species. In this novel transformation, copper(II) triflate was used as catalyst in 1,2-dichloroethane or ethyl acetate and the reaction takes place at 75 °C in 2-16 h.
