5333-40-4

Usage

InChI:InChI=1/C12H16O3/c1-8(2)10-5-4-9(3)6-11(10)15-7-12(13)14/h4-6,8H,7H2,1-3H3,(H,13,14)

Upstream product

• 89-83-8 thymol 
• 79-11-8 chloroacetic acid 
• 79-08-3 bromoacetic acid 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 111304-01-9 methyl 2-(2-isopropyl-5-methylphenoxy)acetate 
• 55129-21-0 2-(2-isopropyl-5-methylphenoxy)ethan-1-ol 
• 31339-06-7 thymoxyacetyl chloride 
• 17693-39-9 4-bromothymoxyacetic acid 
• 636-94-2 2-hydroxyterephthalic acid 
• 99-06-9 3-Carboxyphenol 
• 458530-14-8 (2-isopropyl-5-methyl-phenoxy)-acetic acid p-phenetidide 
• 6459-31-0 2-Isopropyl-4-<2-methylen-butyryl>-5-methyl-phenoxyessigsaeure 
• 19420-59-8 3-hydroxy-4-isopropyl-benzoic acid 
• 958881-78-2 28-carboxymethoxythymol ester of betulin 
• 111719-46-1 2-((Ξ)-4-dimethylamino-benzylidene)-7-isopropyl-4-methyl-benzofuran-3-one 
• 97282-07-0 <3-Methyl-6-isopropyl-phenoxy>-essigsaeure- 
• 97804-99-4 <3-Methyl-6-isopropyl-phenoxy>-essigsaeure- 
• 89-83-8 thymol 

Relevant academic research and scientific papers

PEPTIDES, COMPOUNDS, COMPOSITIONS AND METHODS FOR INHIBITING SOX9 DIMERIZATION

The present application provides SOX9 dimerization inhibitor compounds, compositions, and methods of use thereof. In certain aspects, the SOX9 dimerization inhibitor is a peptide comprising a portion of the SOX9 dimerization motif and a TAT protein to support cell entry which is c-terminal to the SOX9 dimerization motif as set forth in SEQ ID NO:3. In other aspects, the SOX9 dimerization inhibitor is a compound of the general formula I (The applicant is kindly asked to please insert chemical structure here) where one A is H and the other is: (please insert second chemical structure here), and the remaining substituents are as defined in the application.

Shape Similarity by Fractal Dimensionality: An Application in the de novo Design of (?)-Englerin A Mimetics

Molecular shape and pharmacological function are interconnected. To capture shape, the fractal dimensionality concept was employed, providing a natural similarity measure for the virtual screening of de novo generated small molecules mimicking the structurally complex natural product (?)-englerin A. Two of the top-ranking designs were synthesized and tested for their ability to modulate transient receptor potential (TRP) cation channels which are cellular targets of (?)-englerin A. Intracellular calcium assays and electrophysiological whole-cell measurements of TRPC4 and TRPM8 channels revealed potent inhibitory effects of one of the computer-generated compounds. Four derivatives of this identified hit compound had comparable effects on TRPC4 and TRPM8. The results of this study corroborate the use of fractal dimensionality as an innovative shape-based molecular representation for molecular scaffold-hopping.

Microwave (MW), ultrasound (US) and combined synergic MW-US strategies for rapid functionalization of pharmaceutical use phenols

Increasingly stringent regulations aimed at protection of the natural environment have stimulated the search for new synthetic methodologies in organic and medicinal chemistry having no or minimum harmful effect. An interesting approach is the use of alternative activation factors, microwaves (MW) or ultrasounds (US) and also their cross-combination, which has been tested in the fast and efficient creation of new structures. At present, an easy and green hybrid strategy (“Lego” chemistry) is generally recommended for the design of new substances from different chemistry building blocks. Often, selected biologically active components with specific chemical reactivities are integrated by a suitably designed homo- or heterodifunctional linker that modifies the functionality of the starting structure, allowing easy covalent linkage to another molecule. In this study, a fast introduction of heterodifunctional halogenoacidic linker to selected mono-, di- and triphenolic active substances, allowing their functionalization, was investigated. Nucleophilic substitution reaction was chosen to produce final ethers with the reactive carboxylic group from phenols. The functionalization was performed using various green factors initiating and supporting the chemical reactions (MW, US, MW-US). The benefits of the three green supporting methods and different conditions of reactions were analyzed and compared with the results of the reaction performed by conventional methods.

BETULIN DERIVED COMPOUNDS USEFUL AS ANTIBACTERIAL AGENTS

The invention relates to compouns derived from betulin, and to the use thereof as antibacterial agents in pharmaceutical and cosmetic applications.

BETULIN DERIVED COMPOUNDS AS ANTI-FEEDANTS FOR PLANT PESTS

The invention relates to compounds derived from betulin, and to the use thereof in plant pest control, particularly as antifeedants for butterfly larvae, beetles and snails. Further, the invention relates to novel betulin derivatives and methods for the production thereof either directly from betulin, or via intermediates derived therefrom.

Microwave-assisted sinthesis of thymyl ethers and esters in aqueous medium

Various thymyl ethers and esters have been synthesized by reactions of thymol with alkyl halides and acid chlorides, respectively, in aqueous medium under environmentally benign conditions using microwave irradiation. The products are important as potent pest managing agents.

Synthesis of monocyclic &β-lactams incorporating an essential oil constituent in the ring

A series of new monocyclic β-lactams has been prepared using acyl chlorides derived from 1-menthol, thymol and eugenol and Schiff bases derived from aromatic aldehydes and amines, and their antibacterial activity determined.The compounds have been charact

Synthesis of Monocyclic β-Lactams with a Terpenoid Moiety

A series of new monocyclic β-lactams with a terpenoid moiety have been prepared by reaction of schiff bases with appropriate terpenyl acid chlorides in the presence of triethylamine.Their structural assignments are based on elemental analyses and spectral