5334-79-2

Usage

Class

Aromatic compounds

Structure

A brominated derivative of 2,3-dimethylnaphthalene

Applications

a. Building block in the synthesis of pharmaceuticals
b. Building block in the synthesis of agrochemicals
c. Building block in the synthesis of other fine chemicals
d. Reagent in organic synthesis
e. Synthesis of biologically active compounds

Use as a Reagent

Introduces a bromine atom into molecules for further reactions

Interest to Chemists

Versatile applications in organic chemistry

Field of Interest

Organic chemistry

Upstream product

• 581-40-8 2,3-dimethylnaphthalene 
• 75-89-8 2,2,2-trifluoroethanol 
• 93769-24-5 1-<2-(1-Propin-1-yl)phenyl>-2-propanon 

Downstream Products

• 66093-78-5 dibenzo[a,h]-12c,12d-dimethyl-12c,12d-dihydro-pyrene 
• 66093-76-3 trans-12b,12c-dimethyl-12b,12c-dihydrobenzopyrene 
• 19930-50-8 1-(1-Iminobenzyl)-2,3-dimethylnaphthalin 
• 6271-14-3 (2,3-dimethylnaphthalen-1-yl)(phenyl)methanone 
• 27521-96-6 phenyl-1 dimethyl-2,3 naphtalene 
• 51036-97-6 1-(1'-Cyclohexenyl)-2,3-dimethylnaphthalin 

Relevant academic research and scientific papers

Catalytic Asymmetric Dearomatizing Redox Cross Coupling of Ketones with Aryl Hydrazines Giving 1,4-Diketones

An asymmetric Bronsted acid catalyzed dearomatizing redox cross coupling reaction has been realized, in which aryl hydrazines react with ketones to deliver 1,4-diketones, bearing an all-carbon quarternary stereocenter in high enantiopurity.

Antihyperglycemic Activity of Novel Naphthalenyl 3H-1,2,3,5-Oxathiadiazole 2-Oxides

A series of naphthalenyl 3H-1,2,3,5-oxathiadiazole 2-oxides was prepared and tested for antihyperglycemic activity in the db/db mouse, a model for type 2 (non-insulin dependent) diabetes mellitus.Substitution at the 1-,5-, or 8-positions of the naphthalene ring with a halogen was found to be beneficial to antihyperglycemic activity. 4--3H-1,2,3,5-oxathiadiazole 2-oxide (45), one of the most potent compounds in this series, was selected for further pharmacological evaluation.

Synthesis and Solvolysis of (Z)/(E)-1-Methyl-2-vinyl Triflate and 1-Methylene-2-ethyl Triflate

The synthesis and solvolysis of the triflates (Z)/(E)-8 and 20 in various solvents are described.The (E)-triflate 8 reacts in trifluoroethanol by rearrangement via the intermediate naphthyl cation 9 to give the naphthyl ether 22 and the naphthyl triflate