53342-32-8

Upstream product

• 37859-25-9 2-naphthylacetyl chloride 
• 100-51-6 benzyl alcohol 
• 100-39-0 benzyl bromide 
• 581-96-4 2-naphthylacetic acid 
• 40482-44-8 4S-(-)-isopropyl-2-oxazolidinone 
• 2018-89-5 N,N-dimethyl-1-(naphthalene-2-yl)methanamine 
• 201230-82-2 carbon monoxide 
• 1416982-18-7 N,N,N-trimethyl-1-(naphthalen-2-yl)methanaminium trifluoromethanesulfonate 
• 939-26-4 2-bromomethylnaphthyl bromide 
• 13939-06-5 molybdenum hexacarbonyl 

Downstream Products

• 220099-06-9 Difluoro-naphthalen-2-yl-acetic acid benzyl ester 
• 1094027-91-4 benzyl 2-diazo-2-(naphthalen-2-yl)acetate 
• 1374152-84-7 C₂₇H₂₁N₃O₂ 
• 228411-14-1 2,2-dimethyl-(2-naphthyl)acetic acid benzyl ester 

Relevant academic research and scientific papers

Palladium-catalyzed carbonylation of benzylic ammonium salts to amides and esters: Via C-N bond activation

An efficient palladium-catalyzed carbonylation reaction of readily available quaternary ammonium salts with CO is reported for the first time to afford arylacetamides and arylacetic acid esters via benzylic C-N bond cleavage. This protocol features mild reaction conditions under atmospheric pressure of CO, a redox-neutral process without an additional oxidant, and a broad substrate scope for various kinds of amines, alcohols and phenols.

Expedient carbonylation of aryl halides in aqueous or neat condition

An expedient and versatile, microwave-assisted procedure for the carbonylation of aryl halides with boronic acids, alcohols or amines in water or under neat conditions has been developed. The reaction is catalyzed by fluorous, oxime-based palladacycle 1 that shows an excellent recyclable property and low levels of Pd leaching. To demonstrate the usefulness of the protocol, we applied it to the preparation of compounds of pharmaceutical interest, including a precursor of the reverse transcriptase inhibitor, niacin, benzocaine and butamben.

Nonpeptidic, monocharged, cell permeable ligands for the p56lck SH2 domain

p56lck is a member of the src family of tyrosine kinases and plays a critical role in the signal transduction events that lead to T cell activation. Ligands for the p56lck SH2 domain have the potential to disrupt the interaction of p56lck with its substra

Src family SH2 domain inhibitors

This invention relates to compounds of formula (1): wherein Ring a, A, B, C, D, E, R and Q are defined herein. These compounds possess the ability to disrupt the interaction between regulatory proteins possessing one or more SH2 domains and their native ligands.

Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases

Benzylic α,α-difluorosulfonates, α,α-difluorotetrazoles, and α,α- difluorocarboxylates of type 5 and 6 were synthesized and examined as potential phosphate biosteres for PTP1B inhibition. The α,α- difluorosulfonates and α,α-difluorotetrazoles were found t