5337-26-8

Basic information

• Product Name: N-(2,2-dichloro-1-hydroxyethyl)acetamide
• Synonyms: acetamide, N-(2,2-dichloro-1-hydroxyethyl)-
• CAS NO: 5337-26-8
• Molecular Formula: C₄H₇Cl₂NO₂
• Molecular Weight: 172.0099
• Mol File: 5337-26-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 350.8°C at 760 mmHg
• Flash Point: 166°C
• Density: 1.415g/cm³
• Vapor Pressure: 2.55E-06mmHg at 25°C
• Refractive Index: 1.493
• CAS DataBase Reference: N-(2,2-dichloro-1-hydroxyethyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2,2-dichloro-1-hydroxyethyl)acetamide(5337-26-8)
• EPA Substance Registry System: N-(2,2-dichloro-1-hydroxyethyl)acetamide(5337-26-8)

Safety Data

• Hazardous Substances Data: 5337-26-8(Hazardous Substances Data)

Upstream product

• 34243-54-4 N-(2,2-dichlorovinyl)acetamide 
• 60-35-5 acetamide 
• 79-02-7 2,2-dichloroacetaldehyde 

Relevant articles and documents

ELECTROCHEMICAL STUDIES ON HALOAMIDES. PART VIII. ELECTROSYNTHESIS OF N-(HALO)VINYLAMIDES

The electrochemical reduction of N-haloethylamides 1a,b-4a,b (X = OCOCH3, Cl) at a mercury pool cathode in HCON(CH3)2 (or CH3CN) - 0.1 mol dm-3 Et4NClO4 solution has been investigated. 2,2,2-trichloroethyl derivatives 1a-4a (X = OCOCH3, Cl) give rise to the corresponding N-(2,2-dichlorovinyl)amides 5a-8a in good to excellent yields, whereas in the case of N-(2,2-dichloroethyl)amides 1b-4b the course of the reduction depends on the nature of the substituent at N-Cα and/or of the amide moiety.Acetamides 1b (X = OCOCH3, Cl) yield a mixture isomeric 5b, but pyrrolidone derivatives 2b behave differently depending on X.If X = Cl the expected isomeric dehydrohalogenation products 6b are formed, whereas vinylpyrrolidone 6c, in addition to 6b, is formed from 2b, X = OCOCH3.High yields of 6c are attained by treatment of N-(2-chloroethyl)-2-pyrrolidone, 9, with the electrogenerated pyrrolidone anion.