53370-87-9

Usage

Uses

Used in Medical Industry:
ACRYLAMIDO BUFFER is used as a buffering agent for maintaining pH stability in medical formulations. This is important for ensuring the efficacy and safety of drugs and other medical products.
Used in Pharmaceutical Applications:
ACRYLAMIDO BUFFER is used as a pH regulator in the development of injectable hydrogel dressings. These dressings are designed to provide gastric hemostasis and promote wound healing by responding to the pH levels in the body.
Used in Research and Development:
ACRYLAMIDO BUFFER is used as a component in the formulation of various research chemicals and compounds. Its buffering properties make it a valuable tool for maintaining consistent pH levels during experiments and the development of new products.
Used in Cosmetics Industry:
ACRYLAMIDO BUFFER is used as a stabilizing agent in the formulation of cosmetics and personal care products. Its ability to maintain pH stability helps to ensure the effectiveness and longevity of these products.
Used in Environmental Applications:
ACRYLAMIDO BUFFER is used as a pH control agent in various environmental applications, such as water treatment and soil management. Its buffering properties help to maintain optimal conditions for various biological processes and prevent the growth of harmful microorganisms.

InChI:InChI=1/C7H11NO3/c1-2-6(9)8-5-3-4-7(10)11/h2H,1,3-5H2,(H,8,9)(H,10,11)

Upstream product

• 814-68-6 acryloyl chloride 
• 56-12-2 4-amino-n-butyric acid 

Downstream Products

• 442663-80-1 2-(4-acryloylamino-butyrylamino)-3-(4-tert-butoxy-phenyl)-propionic acid tert-butyl ester 
• 219797-99-6 4-Acryloylamino-butyric acid pentafluorophenyl ester 

Relevant academic research and scientific papers

Role of hydrophobicity on structure of polymer-metal complexes

Metal complexation of a series of polymeric gels, with different degrees of ionization, prepared from acrylic acid and acryloyl amino acid monomers (CH2=CHCONH(CH2)nCOOH, where n = 4, 6 and 8), were investigated. The binding of Cu(II) ions to the gels was studied by means of swelling, quantitative determination of the amount of "bound" or complexed Cu(II), and EPR spectroscopy of Cu(II) complexes. Both the amount of Cu(II) and the structure of polymer-Cu(II) complex were influenced by the length of the pendent chain, i.e., "hydrophobicity" of the polymer gels. The metal uptake by the gels increases with increasing "hydrophobicity". Two types of polymer-Cu(II) complexes (monomer and dimer, respectively) were identified by EPR spectroscopy, their concentrations were found to be a function of hydrophilic-hydrophobic balance of the polymer gels.

Synthesis of new cotelomers derived from tris(hydroxymethyl) aminomethane bearing arabinofuranosylcytosine moieties. Preliminary results on their in vitro and in vivo antitumoral activities

As an approach to the development of drug delivery systems, a new class of low macromolecular carriers called telomers bearing both antitumor agent such as arabinofuranosylcytosine (Ara-C) and galactose moieties were synthesized. These compounds were prep

Molecular tailoring of thermoreversible copolymer gels: Some new mechanistic insights

We earlier reported the role of hydrophobic and hydrogen bonding interactions on the transition temperatures of thermoreversible copolymer gels. We show here that the chemical structure of the hydrophobe and its concentration determine the transition temperatures [lower critical solution temperature (LCST)] and the heat of transition of new hydrophobically modified poly(N-isopropyl acrylamide) [PNIPAm] copolymer gels. The gels, prepared by copolymerizing NIPAm monomer with hydrophobic comonomers containing increasing lengths of alkyl side groups and a terminal carboxyl acid group, showed lower LCST and lower heat of transition when compared to pure PNIPAm gel. The experimental results were also compared with theoretical calculations based on a lattice-fluid-hydrogen-bond [LFHB] model. We show experimentally and theoretically that a linear correlation exists between the transition temperature and length of the hydrophobic alkyl side group. Also, in apparent contradiction to previous work, we found a reduction in the heat of transition with increasing hydrophobicity. We propose that the presence of the terminal carboxyl acid group on the hydrophobic side chain of the comonomer prevents the association of water molecules around the hydrophobe, thereby causing a reduction in the heat of transition. The LFHB model supports this argument.

Synthesis of cotelomers derived from tris(hydroxymethyl)acrylamidomethane (THAM) bearing cytosine arabinoside moieties. Preliminary investigation of their biological activity

The telomerization of tris(hydroxymethyl)acrylamidomethane (THAM) and cytosine arabinoside (Ara-C) polymerizable derivatives in the presence of transfer reagent such as alkane or perfluoroalkane thiol is described. The cytotoxic activities of these differ