5338-53-4

Usage

Chemical structure

A synthetic organic compound consisting of a morpholine ring and a ketone functional group.

Functional groups

Contains a morpholine ring and a ketone group.

Precursor

Commonly used as a precursor in the synthesis of various pharmaceuticals and agrochemicals.

Stability

The morpholine ring imparts stability to the compound.

Solubility

The morpholine ring enhances the solubility of the compound.

Building block

Suitable as a building block for drug design and development due to its stability and solubility.

Hydrophobic tail

The tetradecan-1-one portion of the molecule provides a long hydrophobic tail.

Bioavailability

The hydrophobic tail can influence the compound's bioavailability.

Pharmacokinetic properties

The hydrophobic tail can also affect the compound's pharmacokinetic properties.

Applications

Has potential applications in the fields of medicinal chemistry and drug discovery.

Upstream product

• 4394-85-8 4-morpholinecarboxaldehyde 
• 2437-56-1 1-tridecene 
• 7438-09-7 N-methyltetradecanamide 
• 110-91-8 morpholine 
• 16514-82-2 N-Methyl-N-nitrosomyristamide 

Downstream Products

• 25727-93-9 N-tetradecyl morpholine 

Relevant academic research and scientific papers

Regioselective hydrocarbamoylation of 1-alkenes

Nickel/Lewis acid cooperative catalysis derived from [Ni(cod)2], AlEt3, and N-heterocyclic carbene (NHC) effects highly regioselective hydrocarbamoylation of 1-alkenes. Variously substituted formamides and 1-alkenes can be employed to give a range of linear alkanamides regioselectively.

Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes

This invention provides compositions for enhancing penetration of physiologically active agents through the skin or mucosal membranes and for retaining these agents in body tissues, said composition comprising effective amounts of a physiologically-active agent and a compound represented by the general formula STR1 wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0, 1 or 2, except that when X is oxygen, a, b and c are 0, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, STR2 wherein R" is H or halogen, and salts, e.g. acid or quaternary derivatives, thereof. These compositions are useful in topical or transdermal applications of the physiologically-active agent.

Reaction of N-Nitroso- and N-Nitro-N-alkylamides with Amines

Several N-nitroso- and N-nitrocarboxamides have been characterized by 1H and 13C NMR spectroscopy.These compounds react with ammonia and aliphatic amines to afford mainly carboxamides of general formula RCONH2, RCONHR', or RCONR'R''.N-Nitrosocarboxamides and aromatic amines give poor yields of RCONHAr; by contrast, N-nitrocarboxamides and aromatic amines lead to RCONHAr in good yields.The higher thermal stability of the N-nitroamides as compared to N-nitrosoamides is advantageous in this connection; nevertheless, the principal advantage of the NNO2 group appears to be that it activates the nucleophilic attack to the carbonyl of the amide function more than the NNO group, as has been demonstrated by competitive experiments.The reaction of N-nitroso- and N-nitro-N-methylsulfonamides with ammonia and diethylamine has been studied as well; whereas N-methyl-N-nitro-p-toluenesulfonamide reacts as N-nitrocarboxamides, transnitration is predominant with N-methyl-N-nitroso-p-toluenesulfonamide.