5338-65-8

Usage

Uses

Used in Pharmaceutical Industry:
AI3-18274 is used as an antibacterial agent for its ability to inhibit the enzyme dihydropteroate synthase (DHPS), which is involved in the synthesis of folic acid in bacteria. This inhibition prevents the growth and reproduction of bacteria, making it a potential candidate for the development of a new class of antibiotics, particularly against drug-resistant strains.
Used in Research and Development:
AI3-18274 is used as a research compound for further studies to understand its mechanism of action and its potential as a therapeutic agent. This research can help in the development of new strategies to combat drug-resistant bacteria and improve the effectiveness of existing antibiotics.

InChI:InChI=1/C12H23NO2/c1-2-3-4-5-6-7-12(14)13-8-10-15-11-9-13/h2-11H2,1H3

Upstream product

• 110-91-8 morpholine 
• 124-13-0 Octanal 
• 6304-39-8 caprylic hydrazide 
• 58068-80-7 1-(n-octanoyl)benzotriazole 
• 111-64-8 n-octanoic acid chloride 
• 111-87-5 octanol 
• 124-07-2 Octanoic acid 
• 13125-66-1 n-heptylmagnesium bromide 

Downstream Products

• 13063-60-0 N-1-octyl morpholine 

Relevant academic research and scientific papers

XtalFluor-E, an efficient coupling reagent for amidation of carboxylic acids

Amides were produced from carboxylic acids and amines by using XtalFluor-E as an activator. Even poorly reactive carboxylic acids can be transformed to amides. In addition, optically active amines and/or carboxylic acids were not epimerized/racemized during the process.

Direct dehydrogenative amide synthesis from alcohols and amines catalyzed by γ-alumina supported silver cluster

The heterogeneously catalyzed reaction of alcohols with amines to form amides and H2 using the easily prepared and inexpensive heterogeneous catalyst, Ag/Al2O3 has been reported. Aromatic and aliphatic amides are functiona

Leishmanicidal potential of N-substituted morpholine derivatives: Synthesis and structure-activity relationships

A series of N-substituted morpholines 2-20 was synthesised by reacting various acid chlorides and alkyl halides with morpholine (1). All of the synthesised compounds 2-20 were screened for their leishmanicidal effects using amphotericin B (IC50 = 0.24 μg L-1) and pentamidine (IC50 = 2.56 μg mL-1) as standards and a structure-activity relationship (SAR) study was established. The compounds 2 (IC50 = 48 μg mL-1), 3 (IC50 = 30.0 μg mL-1), 10 (IC50 = 41.0 μg mL-1), 15 (IC50 = 33.0 μg mL-1), 16 (IC50 = 35.0 μg mL-1) and 20 (IC50 = 47.0 μg mL-1) showed weak leishmanicidal activities.

Efficient synthesis of acylsilanes using morpholine amides

(Chemical Equation Presented) A general synthesis of acylsilanes from the corresponding morpholine amides and silyllithium species is described. The use of morpholine amides is economical and prevents over-addition by the silyl nucleophile. The procedure cleanly affords acylsilanes in good yields and circumvents the use of stoichiometric copper(I) cyanide typically employed to synthesize these compounds from acid chlorides.

Process for the preparation of carboxylic acid amides by oxidation of aldehydes in the presence of amines

Verfahren zur Herstellung von mono-, bi- oder/und polyfunktionellen Amiden der Formeln (Ia) oder/und (Ib),R1-CO-NR2R3R4R5N-CO-R6-CO- NR2R3aus Aldehyden und Aminen in Gegenwart eines übergangsmetallkatalysators und einem Oxidationsmittel.

Catalytic amination of aldehydes to amides

Aldehydes react in a disproportionation reaction in the presence of rhodium catalysts to yield amines and amides. By adding N-methylmorpholine N-oxide as an oxidant in the presence of catalytic amounts of rhodium, the oxidative amination of aldehydes proceeds selectively to give the corresponding amide. Both aliphatic and aromatic aldehydes react with secondary amines to yield carboxylic acid amides in good to excellent yields.

Synthesis of some diethylphosphono substituted 3H-pyrrolizines

The preparation of various alkyl substituted monophosphonate 3H-pynolizines via a tandem Michael □ Horner-Emmons reaction is reported. These products were prepared from tetraethyl ethylidene gem-bisphosphonate and corresponding 2-acylpyrroles.

Transdermal compositions of 1-oxohydrocarbyl-substituted azacyclohexanes

This invention provides compositions for enhancing penetration of physiologically active agents through the skin or mucosal membranes and for retaining these agents in body tissues, said composition comprising effective amounts of a physiologically-active agent and a compound represented by the general formula STR1 wherein X may represent sulfur, oxygen or nitrogen; a and b may be 0 or 1, c may be 0, 1 or 2, except that when X is oxygen, a, b and c are 0, when X is nitrogen c is 0 and only one of a or b is 1, and when X is sulfur a and b are 0; A is a branched or a straight chain, divalent aliphatic radical having from 0 to 2 double bonds; R' is selected from the group consisting of H, a lower alkyl group having from 1 to 4 carbon atoms, phenyl, lower alkyl or halogen substituted phenyl, acetamido, halogen, piperidinyl, lower alkyl or halogen substituted piperidinyl, carbalkoxy, carboxamide, and alkanoyl; and R is hydrogen or a lower alkyl group having from 1 to 4 carbon atoms, STR2 wherein R" is H or halogen, and salts, e.g. acid or quaternary derivatives, thereof. These compositions are useful in topical or transdermal applications of the physiologically-active agent.