533886-71-4

Upstream product

• 1265278-17-8 (Z)-methyl β-bromo-α-formylaminocinnamate 
• 100-52-7 benzaldehyde 

Downstream Products

• 130740-22-6 5-Phenyl-1-pyridin-3-ylmethyl-1H-imidazole-4-carboxylic acid methyl ester 
• 130740-21-5 Methyl 1-Phenethyl-5-phenylimidazole-4-carboxylate 
• 130740-23-7 1-Methyl-5-phenyl-1H-imidazole-4-carboxylic acid methyl ester 
• 119826-01-6 Methyl 1-benzyl-5-phenylimidazole-4-carboxylate 
• 99972-45-9 methyl 5-phenylthiazole-4-carboxylate 
• 1084793-21-4 methyl 1-[(1S,2S)-2-(benzyloxy)cyclohexyl]-5-phenyl-1H-imidazole-4-carboxylate 
• 1084793-20-3 methyl 1-cyclohexyl-5-phenyl-1H-imidazole-4-carboxylate 
• 947270-98-6 methyl 1-(3-morpholinophenyl)-5-phenyl-1H-imidazole-4-carboxylate 
• 947270-99-7 methyl 1-(2,3-dimethoxyphenyl)-5-phenyl-1H-imidazole-4-carboxylate 
• 947271-04-7 methyl 1-(2,3-dihydro-1H-inden-2-yl)-5-phenyl-1H-imidazole-4-carboxylate 
• 947271-00-3 methyl 5-phenyl-1-[(1S)-1-phenylethyl]-1H-imidazole-4-carboxylate 

Relevant academic research and scientific papers

A Facile Synthesis of Methyl 1,5-Disubstituted Imidazole-4-carboxylates

Various methyl 1,5-disubstituted imidazole-4-carboxylates are synthesized by the reaction of methyl 3-bromo-2-isocyanoacrylates with a variety of primary amines in the presence of triethylamine.

2,4,5-Trisubstituted thiazole building blocks by a novel multi-component reaction

A novel multi-component reaction (MCR) of oxo-components, primary amines, thiocarboxylic acids and 3-bromo-2-isocyanoacrylates yielding 2,4,5-trisubstituted thiazole building blocks is described.

A Novel Synthesis of Methyl 5-Substituted Thiazole-4-carboxylates Using 3-Bromo-2-isocyanoacrylates (BICA)

A novel synthetic method for methyl 5-substituted thiazole-4-carboxylates (5) by the reaction of methyl 3-substituted 3-bromo-2-isocyanoacrylates (BICA) (1) with hydrogen sulfide in the presence of triethylamine in N,N-dimethylformamide was explored, and