5339-13-9Relevant academic research and scientific papers
SIGMA-1 RECEPTOR LIGANDS AND METHODS OF USE
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Page/Page column 42-43, (2010/07/10)
The invention provides compounds of formula I and compositions thereof. The invention further provides methods of using the compounds and compositions. The compounds of the invention can provide high affinity binding to sigma-1 receptors in a mammal. The compounds can exhibit selectivity for the sigma-1 receptor over the sigma-2 receptor. The compounds and compositions of the invention can also be used to treat conditions that involve the sigma-1 receptor, such as addiction, cardiovascular conditions, and cancer, for example, cancer of the breast, lung, prostate, ovarian, colorectal, or the CNS.
Synthesis and characterization of N,N-dialkyl and N-alkyl-N-aralkyl fenpropimorph-derived compounds as high affinity ligands for sigma receptors
Hajipour, Abdol R.,Fontanilla, Dominique,Chu, Uyen B.,Arbabian, Marty,Ruoho, Arnold E.
experimental part, p. 4397 - 4404 (2010/09/12)
The sigma-1 receptor is a unique non-opioid, non-PCP binding site that has been implicated in many different pathophysiological conditions including psychosis, drug addiction, retinal degeneration and cancer. Based on the structure of fenpropimorph, a hig
PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS
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Page/Page column 6, (2008/06/13)
Compounds of Formula I and their pharmaceutically acceptable salts having selective dopamine D3 receptor activity suitable for treating central nervous system disorders. Formula I: R1 is independently H or a C1-C8 alkyl including isomeric forms thereof; R
