5339-24-2

Upstream product

• 138531-36-9 N,N-di-n-propyl-4-nitrophenylacetamide 
• 20264-95-3 2-(4-nitrophenyl)ethyl chloride 
• 142-84-7 di-n-propylamine 
• 104-03-0 4-nitrobenzeneacetic acid 
• 50434-36-1 4-nitrophenylacetyl chloride 
• 29968-78-3 2-(4-nitrophenyl)ethylamine monohydrochloride 
• 106-94-5 propyl bromide 

Downstream Products

• 138531-37-0 4-<2-(N,N-di-n-propylamino)ethyl>-aniline 
• 159418-05-0 4-<2-(N,N-di-n-propylamino)ethyl>-2-nitroacetylanilide 
• 138531-38-1 4-<2-(N,N-di-n-propylamino)ethyl>-2-nitroaniline 
• 138531-39-2 4-(2-Dipropylamino-ethyl)-benzene-1,2-diamine 
• 763061-47-8 N-[2-Chloro-4-(2-dipropylamino-ethyl)-phenyl]-acetamide 
• 159418-04-9 4-<2-(N,N-di-n-propylamino)ethyl>-acetanilide 

Relevant academic research and scientific papers

PHENYLSULFONAMIDE-PHENYLETHYLAMINES USEFUL AS DOPAMINE RECEPTORS

Compounds of Formula I and their pharmaceutically acceptable salts having selective dopamine D3 receptor activity suitable for treating central nervous system disorders. Formula I: R1 is independently H or a C1-C8 alkyl including isomeric forms thereof; R

Partial dopamine receptor agonists with different degrees of intrinsic activity within a series of 2-(4-aminophenyl)-N,N-dipropylethylamine derivatives: Synthetic chemistry and structure-activity relationships

A series of 2-(4-aminophenyl)-N,N-dipropylethylamine derivatives were synthesized and tested for in vivo intrinsic activity at brain dopamine receptors in the rat. Differences in the sensitivity of dopamine receptors pre- and post-synaptically in the reserpine-treated rat were used to estimate the intrinsic activity of the various compounds as dopamine receptor agonists. Thus, the ability of the compounds to antagonize reserpine-induced increase in neostriatal dopamine synthesis and the suppression of spontaneous locomotor activity were taken as pre- and post-synaptic indices, respectively. The compounds in the present series display a gradient of intrinsic activity depending on the substituents in the aromatic ring. The presence of an amino group or an appropriate acylamino group in the 4-position was found to be critical for the biological activity of these compounds as agonists or antagonists. The introduction of halogen or a trifluoromethyl group in the 3-position resulted in high intrinsic activity (ie, agonist activity). The incorporation of a methyl group in the 3-position or halogens in the 3,5-positions resulted in a gradual decrease in intrinsic activity at rat brain dopamine receptors resulting in a series of compounds ranging from a full agonist to dopamine receptor blockade.

Design, synthesis and properties of several heterocyclic dopaminergic ligands

Two series of non-catechol dopamine (DA) bioisosteres with the hydroxyl groups on the benzene ring replaced by N-H groups were synthesized using phenethylamine as a parent molecule. Compounds from the first series (1-9) contained a primary amine group, wh