53393-11-6

Usage

InChI:InChI=1/C9H12N2S/c1-11(9(10)12)7-8-5-3-2-4-6-8/h2-6H,7H2,1H3,(H2,10,12)

Upstream product

• 540-72-7 sodium thiocyanide 
• 103-67-3 benzyl-methyl-amine 
• 68315-07-1 C₂₇H₂₅N₂PS 
• 66365-41-1 triphenylphosphine-thiocyanogen 
• 34065-04-8 N-benzyl-N-methyl cyanamide 
• 114324-55-9 1-(N-benzyl-N-methylthiocarbamoyl)imidazole 

Downstream Products

• 89563-51-9 2-(N-benzyl-N-methylamino)-4-methyl-5-nitrothiazole 
• 85656-43-5 4-benzyl-2-(N-benzyl-N-methylamino)thiazole 
• 85656-33-3 ethyl 4-benzyl-2-(N-benzyl-N-methylamino)thiazole-5-carboxylate 
• 85656-46-8 2-(N-benzyl-N-methylamino)-4-t-butylthiazole 
• 85656-41-3 2-(N-benzyl-N-methylamino)-4-methylthiazole 
• 85656-45-7 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole 
• 89563-54-2 2-(N-benzyl-N-methylamino)-4-isopropyl-5-nitrothiazole 
• 89563-65-5 2-(N-benzyl-N-methylamino)-4-methyl-5-trifluoroacetylthiazole 
• 89563-71-3 2-(N-benzyl-N-methylamino)-4-isopropyl-5-trifluoroacetylthiazole 
• 89563-75-7 2-(N-benzyl-N-methylamino)-4-t-butyl-5-trifluoroacetylthiazole 
• 89563-60-0 2-(N-benzyl-N-methylamino)-4-(4-bromophenyl)-5-nitrothiazole 
• 89563-68-8 4-benzyl-2-(N-benzyl-N-methylamino)-5-trifluoroacetylthiazole 
• 89563-77-9 2-(N-benzyl-N-methylamino)-4-(4-bromophenyl)-5-trifluoroacetylthiazole 
• 89563-80-4 2-(N-benzyl-N-methylamino)-4-(4-methoxyphenyl)-5-trifluoroacetylthiazole 

Relevant academic research and scientific papers

Activation of Dithiocarbamate by 2-Halothiazolium Salts

Activation of dithiocarbamate salts with 2-halo-3-alkyl-4-phenylthiazolium salt and subsequent one-pot nucleophilic reaction with N, S, and O nucleophiles provided substituted thioureas, dithiocarbamates, and thiocarbamates or amides, respectively, under very mild conditions.A useful thiocarbonyl-transfer reaction is also described that consists of activation of imidazolodithiocarbamate and a subsequent one-pot nucleophilic reaction. (Thiocarbonyl)diimidazole is generated in situ.

2-(N,N-Disubstituted Amino)thiazoles with Electron-withdrawing Groups at Position 5: Prepaeation and Investigation on Structural Features

A convenient procedure for preparing N-mono- and NN-di-substituted cyanamides from cyanogen bromide has been developed.N,N-Disubstituted thioureas, obtained from the cyanamides, were condensed with α-bromo-α-cyanoketones to give 5-cyano-2-(N,N-disubstituted amino)thiazoles and with α-bromo-ketones to give 2-(N,N-disubstituted amino)thiazoles.Substitution in the latter products afforded 5-trifluoroacetyl- and 5-nitro-2-(N,N-disubstituted amino)thiazoles; nitration is greatly facilitated by the presence of a 4-aryl group.The average values of the barriers of rotation of the barriers to rotation of the 2-NR2 groups (ΔG298) in the 5-substituted thiazoles were established by variable temperature 1H n.m.r. spectrometry to be 57.4 kJ mol -1 (5-NO2), 56.2 (5-COCF3), and 51.5 (5-CN).I.r. examination showed that the 5-trifluoroacetyl compounds adopt one rotational form preferentially; this is probably the carbonyl O,S-syn-conformation.