89563-71-3

Basic information

• Product Name: 2-(N-benzyl-N-methylamino)-4-isopropyl-5-trifluoroacetylthiazole
• CAS NO: 89563-71-3
• Molecular Weight: 342.385
• Mol File: 89563-71-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(N-benzyl-N-methylamino)-4-isopropyl-5-trifluoroacetylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(N-benzyl-N-methylamino)-4-isopropyl-5-trifluoroacetylthiazole(89563-71-3)
• EPA Substance Registry System: 2-(N-benzyl-N-methylamino)-4-isopropyl-5-trifluoroacetylthiazole(89563-71-3)

Safety Data

• Hazardous Substances Data: 89563-71-3(Hazardous Substances Data)

Upstream product

• 103-67-3 benzyl-methyl-amine 
• 53393-11-6 1-benzyl-1-methylthiourea 
• 34065-04-8 N-benzyl-N-methyl cyanamide 
• 85656-45-7 2-(N-benzyl-N-methylamino)-4-(1-methylethyl)thiazole 
• 407-25-0 trifluoroacetic anhydride 

Relevant articles and documents

2-(N,N-Disubstituted Amino)thiazoles with Electron-withdrawing Groups at Position 5: Prepaeation and Investigation on Structural Features

A convenient procedure for preparing N-mono- and NN-di-substituted cyanamides from cyanogen bromide has been developed.N,N-Disubstituted thioureas, obtained from the cyanamides, were condensed with α-bromo-α-cyanoketones to give 5-cyano-2-(N,N-disubstituted amino)thiazoles and with α-bromo-ketones to give 2-(N,N-disubstituted amino)thiazoles.Substitution in the latter products afforded 5-trifluoroacetyl- and 5-nitro-2-(N,N-disubstituted amino)thiazoles; nitration is greatly facilitated by the presence of a 4-aryl group.The average values of the barriers of rotation of the barriers to rotation of the 2-NR2 groups (ΔG298) in the 5-substituted thiazoles were established by variable temperature 1H n.m.r. spectrometry to be 57.4 kJ mol -1 (5-NO2), 56.2 (5-COCF3), and 51.5 (5-CN).I.r. examination showed that the 5-trifluoroacetyl compounds adopt one rotational form preferentially; this is probably the carbonyl O,S-syn-conformation.