533932-27-3

Basic information

• Product Name: 4-(trifluoromethyl)pyridine-3-sulfonyl chloride
• CAS NO: 533932-27-3
• Molecular Weight: 245.61
• Mol File: 533932-27-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(trifluoromethyl)pyridine-3-sulfonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(trifluoromethyl)pyridine-3-sulfonyl chloride(533932-27-3)
• EPA Substance Registry System: 4-(trifluoromethyl)pyridine-3-sulfonyl chloride(533932-27-3)

Safety Data

• Hazardous Substances Data: 533932-27-3(Hazardous Substances Data)

Upstream product

• 3796-24-5 4-trifluoromethylpyridine 
• 936841-70-2 3-bromo-4-(trifluoromethyl)pyridine 

Relevant articles and documents

Utilizing Carbonyl Coordination of Native Amides for Palladium-Catalyzed C(sp3)?H Olefination

PdII-catalyzed C(sp3)?H olefination of weakly coordinating native amides is reported. Three major drawbacks of previous C(sp3)?H olefination protocols, 1) in situ cyclization of products, 2) incompatibility with α-H-containing substrates, and 3) installation of exogenous directing groups, are addressed by harnessing the carbonyl coordination ability of amides to direct C(sp3)?H activation. The method enables direct C(sp3)?H functionalization of a wide range of native amide substrates, including secondary, tertiary, and cyclic amides, for the first time. The utility of this process is demonstrated by diverse transformations of the olefination products.