533935-33-0Relevant academic research and scientific papers
Synthesis and evaluation of aminophosphinic acid derivatives as inhibitors of renal dipeptidase
Gurulingappa, Hallur,Buckhalts, Phillip,Kinzler, Kenneth W.,Vogelstein, Bert,Khan, Saeed R.
, p. 3531 - 3533 (2007/10/03)
Renal dipeptidase (RDP) is an enzyme overexpressed in benign and malignant colorectal tumors. In an effort to identify potent inhibitors of this enzyme, a series of aminophosphinic acid derivatives were synthesized. Compounds 3a and 3c in which the phenyl
Design, synthesis and evaluation of new RDP inhibitors
Gurulingappa, Hallur,Buckhaults, Phillip,Kumar, Srinivas K.,Kinzler, Kenneth W.,Vogelstein, Bert,Khan, Saeed R.
, p. 1871 - 1873 (2007/10/03)
Aminophosphinic acid derivatives were synthesized as potential inhibitors of renal dipeptidase, an enzyme overexpressed in benign and malignant colon tumors. Several compounds showed potent enzyme-inhibitory activity.
