55168-74-6

Usage

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
TRIMETHYL 2-PHOSPHONOACRYLATE is used as a reagent for the synthesis of biologically active molecules, playing a crucial role in the development of new pharmaceuticals and agrochemicals. Its unique structure allows for the creation of a wide range of compounds with potential therapeutic and pesticidal properties.
Used in Vinyl Polymer Stabilization:
In the polymer industry, TRIMETHYL 2-PHOSPHONOACRYLATE is utilized as a stabilizer for vinyl polymers. Its ability to prevent degradation and improve the stability of these polymers makes it a valuable additive in various applications, including plastics and coatings.
Used in Water Treatment Chemical Production:
TRIMETHYL 2-PHOSPHONOACRYLATE also serves as an intermediate in the production of water treatment chemicals. Its role in creating effective water treatment agents contributes to the development of products that ensure clean and safe water supplies.
Used in Organophosphorus Chemistry:
As a useful substrate in organophosphorus chemistry, TRIMETHYL 2-PHOSPHONOACRYLATE is employed in the preparation of various phosphonate derivatives. Its versatility in this field allows for the synthesis of compounds with diverse applications, further expanding its utility in chemical research and development.

InChI:InChI=1/C6H11O5P/c1-5(6(7)9-2)12(8,10-3)11-4/h1H2,2-4H3

Upstream product

• 67-56-1 methanol 
• 50-00-0 formaldehyd 
• 5927-18-4 trimethyl phosphonoacetate 
• 34159-46-1 dimethylphosphonoacetic acid 

Downstream Products

• 123347-16-0 (Z)-2-(Methoxy-phenyl-phosphinoylmethyl)-5-phenyl-pent-2-enoic acid methyl ester 
• 123347-17-1 (E)-2-(Methoxy-phenyl-phosphinoylmethyl)-5-phenyl-pent-2-enoic acid methyl ester 
• 115047-83-1 methyl <1(S)-<(benzyloxycarbonyl)amino>ethyl>(2-carbomethoxy-2-propenyl)phosphinate 
• 87088-48-0 2-(Dimethoxy-phosphoryl)-3-(4-hydroxy-4-methyl-2-methylene-cyclohexyl)-propionic acid methyl ester 
• 123347-20-6 (Z)-2-(Dimethoxy-phosphorylmethyl)-5-phenyl-pent-2-enoic acid methyl ester 
• 123347-21-7 (E)-2-(Dimethoxy-phosphorylmethyl)-5-phenyl-pent-2-enoic acid methyl ester 
• 87088-30-0 4-Cyclohex-1-enyl-2-(dimethoxy-phosphoryl)-butyric acid methyl ester 
• 67488-46-4 2,5-dihydrothiophene-1-carboxylic acid methyl ester 
• 533935-33-0 2-[(1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-methoxy-phosphinoylmethyl]-3-(4-iodo-phenyl)-acrylic acid methyl ester 
• 533935-34-1 2-[(1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-methoxy-phosphinoylmethyl]-3-(4-iodo-phenyl)-acrylic acid methyl ester 
• 129486-10-8 2-[(1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-methoxy-phosphinoylmethyl]-3-cyclohexyl-acrylic acid methyl ester 
• 129486-09-5 2-[(1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-methoxy-phosphinoylmethyl]-3-cyclohexyl-acrylic acid methyl ester 
• 791836-59-4 2-[(1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-methoxy-phosphinoylmethyl]-3-(4-trifluoromethyl-phenyl)-acrylic acid methyl ester 
• 791837-00-8 2-[(1-tert-butoxycarbonylamino-2-cyclohexyl-ethyl)-methoxy-phosphinoylmethyl]-3-(4-trifluoromethyl-phenyl)-acrylic acid methyl ester 

Relevant academic research and scientific papers

A practical large-scale synthesis of 3-carbomethoxy-3-sulfolene

A simple, efficient one-flask procedure for the large-scale preparation of 3-carbomethoxy-3-sulfolene from trimethylphosphonoacetate is described. The procedure incorporates a cheap and simple sulfide to sulfone oxidation using Oxone. No chromatography or intermediate purification steps are involved and the product is isolated by crystallisation.

A practical and efficient synthesis of 6-carboalkoxy-13-cycloalkyl-5H- indolo[2,1-a][2]benzazepine-10-carboxylic acid derivatives

A convenient and practical synthesis of 6-carboalkoxy-13-cycloalkyl-5H- indolo[2,1-a][2]benzazepine-10-carboxylic acid derivatives (6) has been developed. The key step in the synthesis utilizes an intramolecular tandem reaction sequence of a Michael addition followed by a Horner-Wadsworth-Emmons (HWE) olefination reaction between hemi-aminal 11 and methyl 2-(dimethoxyphosphoryl)acrylate 12. The ring construction occurred efficiently and purification of the products 6 was straightforward. The C-10 methyl ester of 6a was hydrolyzed selectively to the carboxylic acid 13 while the olefin of 6d was converted to the cyclopropane 14 using trimethylsulfoxonium iodide in DMSO in the presence of NaH.

Cyclopropyl Fused Indolobenzazepine HCV NS5B Inhibitors

The disclosure provides compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and may be useful in treating those infected with HCV.

CYCLOPROPYL FUSED INDOLOBENZAZEPINE HCV NS5B INHIBITORS

The invention encompasses compounds of formula (I) as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.

Compounds for the Treatment of Hepatitis C

The invention encompasses compounds of formula I as well as compositions and methods of using the compounds. The compounds have activity against hepatitis C virus (HCV) and are useful in treating those infected with HCV.