533939-05-8 Usage
Derivative of pyrrolopyridine
The compound is a modified version of the pyrrolopyridine structure.
Ethyl and methyl groups attached
The compound has an ethyl group and two methyl groups attached to the amine group.
Tertiary amine
The presence of three organic groups attached to the nitrogen atom makes it a tertiary amine.
Potential applications in medicinal chemistry and drug discovery
The compound has structural and pharmacological properties that make it useful in the development of pharmaceuticals and agrochemicals.
Safety protocols
It is important to handle this chemical with care and follow safety protocols during its synthesis and use.
Check Digit Verification of cas no
The CAS Registry Mumber 533939-05-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 5,3,3,9,3 and 9 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 533939-05:
(8*5)+(7*3)+(6*3)+(5*9)+(4*3)+(3*9)+(2*0)+(1*5)=168
168 % 10 = 8
So 533939-05-8 is a valid CAS Registry Number.
InChI:InChI=1/C12H17N3/c1-4-10-5-6-11-9(8-15(2)3)7-13-12(11)14-10/h5-7H,4,8H2,1-3H3,(H,13,14)
533939-05-8Relevant articles and documents
Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications
Van Zandt, Michael C.,Doan, Brian,Sawicki, Diane R.,Sredy, Janet,Podjarny, Alberto D.
, p. 2006 - 2008 (2009)
Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acid aldose reductase inhibitors. The lead candidate, [6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyri din-1-yl]acetic acid example 16, inhibits aldose reductase with an IC50 of 8 nM, while being inactive against aldehyde reductase (IC50 > 100 μM), a related enzyme involved in the detoxification of reactive aldehydes.