533939-05-8

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridine-3-methanamine,6-ethyl-N,N-dimethyl-(9CI)
• Synonyms: 1H-Pyrrolo[2,3-b]pyridine-3-methanamine,6-ethyl-N,N-dimethyl-(9CI);1H-Pyrrolo[2,3-b]pyridine-3-methanamine, 6-ethyl-N,N-dimethyl-;1-(6-ethyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-N,N-dimethylmethanamine
• CAS NO: 533939-05-8
• Molecular Formula: C12H17N3
• Molecular Weight: 203.28
• Product Categories: ETHYL
• Mol File: 533939-05-8.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 317.9ºC at 760 mmHg
• Flash Point: 146.1ºC
• Appearance: /
• Density: 1.101g/cm3
• Vapor Pressure: 0.000373mmHg at 25°C
• Refractive Index: 1.611
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine-3-methanamine,6-ethyl-N,N-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine-3-methanamine,6-ethyl-N,N-dimethyl-(9CI)(533939-05-8)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine-3-methanamine,6-ethyl-N,N-dimethyl-(9CI)(533939-05-8)

Safety Data

• Hazardous Substances Data: 533939-05-8(Hazardous Substances Data)

Usage

Derivative of pyrrolopyridine

The compound is a modified version of the pyrrolopyridine structure.

Ethyl and methyl groups attached

The compound has an ethyl group and two methyl groups attached to the amine group.

Tertiary amine

The presence of three organic groups attached to the nitrogen atom makes it a tertiary amine.

Potential applications in medicinal chemistry and drug discovery

The compound has structural and pharmacological properties that make it useful in the development of pharmaceuticals and agrochemicals.

Safety protocols

It is important to handle this chemical with care and follow safety protocols during its synthesis and use.

InChI:InChI=1/C12H17N3/c1-4-10-5-6-11-9(8-15(2)3)7-13-12(11)14-10/h5-7H,4,8H2,1-3H3,(H,13,14)

Upstream product

• 533939-04-7 6-ethyl-1H-pyrrolo[2,3-b]pyridine 
• 68-12-2 N,N-dimethyl-formamide 

Relevant articles and documents

Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications

Efforts to identify treatments for chronic diabetic complications have resulted in the discovery of a novel series of highly potent and selective [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl] acetic acid aldose reductase inhibitors. The lead candidate, [6-methyl-3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyri din-1-yl]acetic acid example 16, inhibits aldose reductase with an IC50 of 8 nM, while being inactive against aldehyde reductase (IC50 > 100 μM), a related enzyme involved in the detoxification of reactive aldehydes.