53397-80-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Pyridinecarboxylic acid, 5-(aminomethyl)-(9CI) is used as an intermediate in the synthesis of various pharmaceuticals for its potential therapeutic properties. It is particularly being studied for its potential in the treatment of neurodegenerative diseases and inflammation due to its unique chemical structure and properties.
Used in Agrochemical Industry:
2-Pyridinecarboxylicacid,5-(aminomethyl)-(9CI) is also used as a building block in the development of agrochemicals, contributing to the creation of new antifungal and antibacterial agents. Its versatility in chemical synthesis allows for the development of effective solutions to combat various agricultural challenges.
Used in Research and Development:
2-Pyridinecarboxylic acid, 5-(aminomethyl)-(9CI) is utilized in research and development settings to explore its potential applications in various fields. Its unique properties make it a promising candidate for further studies and innovations, particularly in the areas of medicine and agriculture.

Upstream product

• 24202-68-4 5-carbamoyl-pyridine-2-carboxylic acid methyl ester 
• 76196-66-2 Methyl 5-cyanopyridine-2-carboxylate 

Relevant academic research and scientific papers

Medicinal Chemical Studies on Antiplasmin Drugs. VI. Aza Analogs of 4-Aminomethylbenzoic Acid

Four aza analogs of 4-aminomethylbenzoic acid (1) were prepared as part of a search for new antiplasmin drugs. 5-Aminomethylpyridine-2-carboxylic acid (5) was prepared by the hydrogenation of methyl 5-cyanopyridine-2-carboxylate (4), followed by alkaline hydrolysis.Similarly, 6-aminomethylpyridine-3-carboxylic acid (7) was prepared from ethyl 6-cyanopyridine-3-carboxylate (6). 5-Aminomethylpyrimidine-2-carboxylic acid (12) was obtained from methyl 5-methylpyrimidine-2-carboxylate (8) via the phthalimido derivative (10). 2-Aminomethylpyrimidine-5-carboxylic acid (25) was obtained by the reaction of benzyloxycarbonylaminoacetamidine (22) with ethoxycarbonylmalonaldehyde (18) in acetic acid, followed by deblocking of the protected groups.Treatment of benzoylaminoacetamidine (14) with acetylacetone (15) in acetic acid provided 2-benzoylaminomethyl-4,6-dimethylpyrimidine (16), whereas in the presence of K2CO3, 2-amino-3-benzoylamino-4,6-dimethylpyridine (17) was obtained together with a trace of 16.No compound showed more potent antiplasmin activity than tranexamic acid (2), but 5 was more active than 1.Keywords - antiplasmin drug; 4-aminomethylbenzoic acid; tranexamic acid; bioisostere; aminomethylpyridinecarboxylic acid; aminomethylpyrimidinecarboxylic acid; pyridine ring closure; pyrimidine ring closure; benzoylaminoacetamidine; benzyloxycarbonylaminoacetamidine