5340-12-5

Usage

Uses

Used in Chemical Reactions and Organic Syntheses:
(1E)-bis[1-(3-nitrophenyl)ethylidene]hydrazine is used as a reagent or intermediate in various chemical reactions and organic syntheses due to its unique structure and properties.
Used in Pharmaceutical Industry:
(1E)-bis[1-(3-nitrophenyl)ethylidene]hydrazine is used as a building block in the pharmaceutical industry for the synthesis of other organic compounds, potentially contributing to the development of new drugs and therapeutic agents.
It is important to handle (1E)-bis[1-(3-nitrophenyl)ethylidene]hydrazine with care, as it may present hazards if not managed properly.

Upstream product

• 121-89-1 3-Nitroacetophenone 
• 22107-29-5 1-(3-nitro-phenyl)-ethanone semicarbazone 
• 56588-06-8 1-(3-nitrophenyl)-1-ethanone hydrazone 

Downstream Products

• 1314243-20-3 1-methyl-7-nitro-3,4-diphenylisoquinoline 
• 77635-38-2 1-(3-nitro-phenyl)-ethanone-phenylhydrazone 

Relevant academic research and scientific papers

Cp*Co(iii)-catalyzed annulation of azines by C-H/N-N bond activation for the synthesis of isoquinolines

Herein, an efficient, atom economic and external oxidant free approach has been disclosed for the synthesis of isoquinolines. Azines were employed for annulation reactions with alkynes via sequential C-H/N-N bond activation using an air-stable cobalt catalyst. The method takes advantage of the incorporation of both the nitrogen atoms of azines into the desired isoquinoline products, offering the highest atom economy. In addition, the developed protocol works under external oxidant as well as silver salt free conditions. Furthermore, the established methodology features a relatively broad substrate scope with high product yields and scalability up to the gram level.

Rapid and Atom Economic Synthesis of Isoquinolines and Isoquinolinones by C–H/N–N Activation Using a Homogeneous Recyclable Ruthenium Catalyst in PEG Media

Herein, we report an atom-efficient, rapid, green, and sustainable approach to synthesize isoquinolines and isoquinolinones using a homogeneous recyclable ruthenium catalyst in PEG Media assisted by microwave energy. Dibenzoylhydrazine was used for C–H/N–N activation reactions for the first time in combination with ketazine as oxidizing directing groups for annulation reactions with internal alkynes. The developed protocol is environmentally benign due to significantly shortened times with an easy extraction method, higher atom economy, external oxidant and silver or antimony salt free conditions, applicability to a gram scale synthesis, use of biodegradable solvent and wide substrate scope with higher product yields. Moreover, it is worth noting that the established methodology allowed reuse of the catalytic system for up to five successive runs with minimal loss in activity.

Facile method for the conversion of semicarbazones/thiosemicarbazones into azines (Under Microwave Irradiation) and oxadiazoles (By Grinding)

In an effective transformation, semicarbazones/thiosemicarbazones are smoothly converted into azines under microwave irradition. Oxadiazoles are also obtained from semicarbazones by reaction with bromine generated in situ via a grinding reaction in the solid phase. Taylor &Francis Group, LLC.

Synthesis of azines in solid state: Reactivity of solid hydrazine with aldehydes and ketones

Highly conjugated azines were prepared by solid state grinding of solid hydrazine and carbonyl compounds such as aldehydes and ketones, using a mortar and a pestle. Complete conversion to the azine product is generally achieved at room temperature within 24 h, without using solvents or additives. The solid-state reactions afford azines as the sole products with greater than 97% yield, producing only water and carbon dioxide as waste.