53409-48-6

Upstream product

• 10234-72-7 pyrazolidin-3-one 
• 2043-61-0 cyclohexanecarbaldehyde 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1321112-16-6 (E)-ethyl 2-(3-cyclohexyl-7-oxotetrahydropyrazolo[1,2-a]pyrazol-1(5H)-ylidene)propanoate 
• 1591838-90-2 5-cyclohexyl-6,7-bis(phenylsulfonyl)tetrahydro-1H,5H-pyrazolo[1,2-a]pyrazol-1-one 

Relevant academic research and scientific papers

Visible-Light-Mediated α-Amino Alkylation of Azomethine Imines: An Approach to N-(β-Aminoalkyl)pyrazolidinones

Herein, a mild and robust photocatalytic protocol for the combination of amino and pyrazolidinone functionalities through a radical α-amino alkylation of azomethine iminium ions is demonstrated. This method presents a high functional group tolerance provi

Br?nsted Acid-Catalyzed (4 + 3) Cyclization of N, N′-Cyclic Azomethine Imines with Isatoic Anhydrides

A Br?nsted acid-catalyzed (4 + 3) cyclization of N,N′-cyclic azomethine imines with isatoic anhydrides has been discovered, which constructs seven-membered nitrogenous heterocyclic frameworks with overall high yields (up to 98% yield). This reaction repre

Asymmetric [3 + 2] Cycloaddition Employing N, N′-Cyclic Azomethine Imines Catalyzed by Chiral-at-Metal Rhodium Complex

An efficient asymmetric 1,3-dipolar cycloaddition of α,β-unsaturated 2-acyl imidazoles with N,N′-cyclic azomethine imines catalyzed by a chiral-at-metal rhodium complex is reported. The corresponding N,N′-bicyclic pyrazolidine derivatives with three conti

Phosphine-catalyzed [3+2] cycloaddition reactions of azomethine imines with electron-deficient alkenes: A facile access to dinitrogen-fused heterocycles

An efficient method for the phosphine-catalyzed [3+2] cycloaddition reaction of azomethine imines with diphenylsulfonyl alkenes to give dinitrogen-fused bi- or tricyclic heterocyclic compounds in high yields has been described. Moreover, two phenylsulfony

Catalyst-free synthesis of N -(1,7-dioxotetrahydropyrazolo[1,2-a]pyrazol-2- yl)benzamide derivatives by 1,3-dipolar cycloaddition and rearrangement

N-(1,7-Dioxotetrahydropyrazolo[1,2-a]pyrazol-2-yl)-benzamide derivatives, a novel class of compounds, were synthesized by 1,3-dipolar cycloaddition of azomethine imines with azlactones and subsequent rearrangement. The reaction can be completed rapidly under mild conditions without a catalyst. Georg Thieme Verlag Stuttgart New York.

Dirhodium(ii)-catalyzed formal [3+2+1]-annulation of azomethine imines with two molecules of a diazo ketone

A highly diastereoselective formal [3+2+1]-cycloaddition reaction that produces multi-functionalized bicyclic pyrazolidinone derivatives is achieved in moderate to high yield by Rh2(4S-MPPIM)4-catalyzed reaction of azomethine imines with two molecules of a diazo ketone. The Royal Society of Chemistry 2013.

Copper(I) acetate-catalyzed cycloaddition between azomethine imines and propiolates under additive-free conditions

Because propiolates easily undergo base-catalyzed self-Michael addition, most popular catalytic systems in CuAAC cannot be used in the cycloaddition between azomethine imines and propiolates, because such reactions usually require the use of tertiary amin

Phosphine-catalyzed [3 + 2] and [3 + 3] annulations of azomethine imines with ethyl 2-butynoate

The phosphine-catalyzed [3 + 2] and [3 + 3] annulation reactions of azomethine imines and ethyl 2-butynoate were developed, providing 1,2-dinitrogen-containing heterocycles tetrahydropyrazolopyrazolones and tetrahydropyrazolopyridazinones in moderate to good yields.

Phosphine-catalyzed annulations of azomethine imines: Allene-dependent [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] pathways

In this paper we describe the phosphine-catalyzed [3 + 2], [3 + 3], [4 + 3], and [3 + 2 + 3] annulations of azomethine imines and allenoates. These processes mark the first use of azomethine imines in nucleophilic phosphine catalysis, producing dinitrogen

A new copper-catalyzed [3 + 2] cycloaddition: Enantioselective coupling of terminal alkynes with azomethine imines to generate five-membered nitrogen heterocycles

A copper-catalyzed method for the regioselective 1,3-dipolar cycloaddition of azomethine imines to terminal alkynes has been developed. Through the use of a chiral phosphaferrocene-oxazoline ligand, a wide range of substrates can be coupled to generate us