53412-27-4Relevant academic research and scientific papers
Luteinizing hormone releasing hormone and analogs. Synthesis and biological activity
Immer,Nelson,Revesz,Sestanj,Goetz
, p. 1060 - 1065 (1974)
A fragment synthesis of LH RH is described which lends itself to large scale preparation. Fragment 1-3 is coupled with fragment 4-6 followed by reaction with the tetrapeptide 7-10 to yield the unprotected decapeptide. The preparation of analogs follows the same synthetic pattern. The biological activity of the analogs is compared with that of synthetic LH RH.
