Journal of Medicinal Chemistry p. 1060 - 1065 (1974)
Update date:2022-08-05
Topics:
Immer
Nelson
Revesz
Sestanj
Goetz
A fragment synthesis of LH RH is described which lends itself to large scale preparation. Fragment 1-3 is coupled with fragment 4-6 followed by reaction with the tetrapeptide 7-10 to yield the unprotected decapeptide. The preparation of analogs follows the same synthetic pattern. The biological activity of the analogs is compared with that of synthetic LH RH.
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