53412-47-8

Upstream product

• 50-00-0 formaldehyd 
• 123-08-0 4-hydroxy-benzaldehyde 

Downstream Products

• 56490-91-6 4-Hydroxy-3-(methylsulfonylmethyl)-benzaldehyd 
• 54030-32-9 4-hydroxy-3-(hydroxymethyl)benzaldehyde 
• 865717-45-9 [(R)-2-(2,2-Dimethyl-4H-benzo[1,3]dioxin-6-yl)-2-((2R,6S)-6-methyl-tetrahydro-pyran-2-yloxy)-ethyl]-[6-(4-phenyl-butoxy)-hexyl]-amine 
• 135271-47-5 (R)-(-)-salmeterol 
• 81998-09-6 α-Aminomethyl-4-hydroxy-3-(methylsulfonylmethyl)-benzylalkohol 
• 56490-57-4 4-Benzyloxy-3-(methylsulfonylmethyl)-benzaldehyd 
• 132930-88-2 2-Hydroxy-5-formylbenzylphosphonic acid diethyl ester 
• 54030-33-0 2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-carboxaldehyde 
• 135271-47-5 (S)-Salmeterol 
• 590410-69-8 (R)-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)-2-(6-(4-phenylbutoxy)hexylamino)ethanol 
• 1355963-67-5 DABI 
• 1355963-63-1 3-((bis(pyridin-2-ylmethyl)amino)methyl)-4-hydroxybenzaldehyde 

Relevant academic research and scientific papers

2-substituted methyl-4-substituted amino methylphenol derivative and medicinal use thereof

The invention relates to a 2-substituted methyl-4-substituted amino methylphenol derivative represented by a formula (I) shown in the description and pharmaceutically acceptable salts, isomers, prodrugs and pharmaceutical compositions thereof. The compoun

BIOFILM FORMATION INHIBITOR

PROBLEM TO BE SOLVED: To provide a substance that can effectively inhibit biofilm formation. SOLUTION: A biofilm formation inhibitor has a compound represented by the following formula (I) as an active ingredient (where R1, R2, Rsup

A bezoimidazole-based highly selective and low-background fluorescent sensor for Zn2+

In this article, a new benzoimidazole based Zn2 + fluorescence sensor DABI has been prepared. The sensor displays a rapid and a linear response to Zn2 + with a red-shifted 100-fold turn-on signal from the dark background. The presenc

Enantioselective synthesis of (R)-salmeterol employing an asymmetric Henry reaction as the key step

A practical synthesis of (R)-salmeterol has been accomplished from 3-bromo salicylaldehyde, which involved a Cu(II)-sparteine complex catalyzed asymmetric Henry reaction as the key step. (R)-Salmeterol can be obtained in 39% overall yield and 95% ee.

A short stereoselective synthesis of (R)-salmeterol

A short, highly stereoselective oxy-Michael approach to the total synthesis of the β2-agonist, (R)-salmeterol is described. Georg Thieme Verlag Stuttgart.

Phosphorylated derivatives of L-dopa and compositions and methods for increasing the melanin content in mammalian skin and hair

A phosphorylated derivative of L-dopa of the formula STR1 wherein when X is STR2 wherein Z is --CH 2, N, S or a linkage other than oxygen which renders the phosphate group resistant to hydrolysis by phosphatase enzymes in tissues and biological fluids,then Y is OQ, wherein Q is H or an alkyl with one to twelve carbon atoms, orwherein X is OQ, then Y is STR3 wherein R'' is hydrogen or a pharmaceutically acceptable cation and R is a moiety which increases hydropobicity. The phosphorylated derivative of L-dopa is useful as an agent to increase the melanin content in mammalian skin and hair.

Adrenergic agents. III. Synthesis and adrenergic activity of some catecholamine analogs bearing a substituted sulfonyl or sulfonylalkyl group in the meta position

The m phenolic group of catecholamine β adrenergic agonists may be replaced by various functionalities capable of undergoing H bonding. Considerable latitude in the nature of the OH simulating group is permissible with retention of activity; however, the most extensively studied analogs are ones in which a mobile proton is attached to an O or N atom. In a search for new selective bronchodilators a series of catecholamine analogs bearing a substituted sulfonyl or sulfonylalkyl group in the meta position (i.e., groups in which the mobile H is attached to a C atom) was examined. These compounds were studied for β adrenergic agonist activity in vitro by measuring their ability to relax tracheal smooth muscle and to increase the rate of spontaneously beating right atria of guinea pigs. Adrenergic activity was influenced by the nature of the aklylene bridge between the sulfonyl and aromatic groups, branching of the ethanolamine side chain, stereochemistry, and substitution of the sulfonyl and amino groups. β Adrenergic blockade was noted for some compounds having the sulfonyl attached directly to the ring. Greatest β adrenergic agonist potency and tissue selectivity was observed with a m MeSO2CH2 substituent. One of these compounds, α [[(1,1 dimethylethyl)amino]methyl] 4 hydroxy 3 [(methylsulfonyl)methyl]benzenemethanol hydrochloride (sulfonterol hydrochloride, USAN), was studied more extensively in animals and is presently being examined for bronchodilator activity in man.