53413-67-5 Usage
Uses
Different sources of media describe the Uses of 53413-67-5 differently. You can refer to the following data:
1. 1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene is a useful research chemical.
2. 4,5-Dimethoxy-2-nitrobenzyl bromide (DMNB bromide, 6-nitroveratryl bromide) is suitable reagent used in the synthesis of N-(4,5-dimethoxy-2-nitrobenzyl)vanillylamine which forms caged vanilloid. It may be used in the synthesis of the following:4-(4′,5′-dimethoxy-2-nitrobenzyloxy)benzaldehyde, a DMNB-caged aldehydeN-[4-[(4,5-dimethoxy-2-nitrobenzyl)oxy]-3-methoxybenzyl]acetamidecaged derivative of pyridostatin ([C]-PDS)photosensitive polyimide (PI-DMNB)caged β-ecdysone4-tert-butyldimethylsilyloxy-1-(2-deoxy-3,5-di-O-toluoyl-β-D-ribofuranosyl)-2-(6-nitroveratrylthio)-1H-benzimidazole, an intermediate in synthesis of phosphoramidite bearing 4-hydroxy-2-mercaptobenzimidazole (SBNV) nucleobasealkylation of dihydrofluorescein4-(4′,5′-Dimethoxy-2′-nitrobenzyloxy)benzaldehyde
General Description
4,5-Dimethoxy-2-nitrobenzyl bromide (DMNBB, 1-(Bromomethyl)-4,5-dimethoxy-2-nitrobenzene) is a 4,5-dimethoxy-2-nitrobenzyl derivative. 4,5-Dimethoxy-2-nitrobenzyl (DMNB) group of DMNBB is used as a photolabile protecting group in caging technology to develop pro-drugs. Synthesis of 1-(bromomethyl)-4,5-dimethoxy-2-nitrobenzene by using 6-nitroveratraldehyde as starting reagent has been reported.
Check Digit Verification of cas no
The CAS Registry Mumber 53413-67-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,4,1 and 3 respectively; the second part has 2 digits, 6 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 53413-67:
(7*5)+(6*3)+(5*4)+(4*1)+(3*3)+(2*6)+(1*7)=105
105 % 10 = 5
So 53413-67-5 is a valid CAS Registry Number.
InChI:InChI=1/C9H10BrNO4/c1-14-8-3-6(5-10)7(11(12)13)4-9(8)15-2/h3-4H,5H2,1-2H3
53413-67-5Relevant articles and documents
Synthesis and evaluation of “Ama-Flash”, a photocaged amatoxin prodrug for light-activated RNA Pol II inhibition and cell death
Matinkhoo, Kaveh,Perrin, David M.,Pryyma, Alla,Wong, Antonio A. W. L.
supporting information, p. 9558 - 9561 (2021/09/28)
Amanitin is used extensively as a research tool to inhibit RNA Pol II thereby implicating its role in mRNA transcription. Recently, amanitin has gained traction as a toxic payload for targeted therapy. Here we report the first-ever photocaged amanitin analog, that is non-toxic and can be pre-loaded into cells. Light provides a means to inhibit RNA Pol II and provoke cell death on-demand.
Photolabile beta-dicarbonyl compounds
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Paragraph 0100, (2020/02/18)
The present disclosure provides a redox initiator system for initiating polymerization comprising an oxidizing agent, a photolabile reducing agent, and a transition metal complex that participates in a redox cycle. On exposure to actinic radiation, such as UV, the photolabile compound photolyzes, releasing the reducing agent and initiating the redox-initiated polymerization.
Cascade photocaging of diazeniumdiolate: A novel strategy for one and two photon triggered uncaging with real time reporting
Behara, Krishna Kalyani,Rajesh,Venkatesh, Yarra,Pinninti, Bhaskar Rao,Mandal, Mahitosh,Singh, N. D. Pradeep
, p. 9470 - 9473 (2017/09/01)
We report a new strategy, viz. cascade photocaging, for protecting diethylamine diazeniumdiolate (O2-position), a light sensitive molecule. Upon photolysis, the cascade photocage at first releases the light activatable linker (latent fluorophore) O2-caged diazeniumdiolate, which undergoes spontaneous 1,8-elimination, triggering the release of the diazeniumdiolate anion and the fluorophore.
