53424-53-6Relevant academic research and scientific papers
Ring-Opening/Recyclization Cascades of Monoactivated Cyclopropanes
Mishra, Uttam K.,Patel, Kaushalendra,Ramasastry, S. S. V.
, (2020)
A variety of cyclopropyl aryl ketones undergo uncatalyzed cascade ring-opening/recyclization reactions to generate indenones and fluorenones. In addition, a new strategy to access 3-hydroxyindanones possessing two contiguous stereogenic centers, one of th
Copper-mediated/catalyzed oxyalkylation of alkenes with alkylnitriles
Bunescu, Ala,Wang, Qian,Zhu, Jieping
supporting information, p. 14633 - 14636 (2015/01/09)
A copper-promoted oxyalkylation of alkenes with alkylnitriles has been developed. The protocol provides rapid access to phthalides (γ-lactones) or isochromanones (d-lactones) via the formation of a C(sp3)-C(sp3) and a C(sp3)-O bond with the generation of up to two quaternary carbon atoms. Mechanistic studies suggest that this reaction is initiated by the formation of the C(sp3)-C(sp3) bond rather than the C(sp3)-O bond. Catalytic conditions were subsequently developed using carboxylic acid as an internal nucleophile.
