53427-77-3

Basic information

• Product Name: 2(1H)-Pyridinone, 1-(4-methoxyphenyl)-5-methyl-
• CAS NO: 53427-77-3
• Molecular Formula: C13H13NO2
• Molecular Weight: 215.252
• Mol File: 53427-77-3.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: 2(1H)-Pyridinone, 1-(4-methoxyphenyl)-5-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2(1H)-Pyridinone, 1-(4-methoxyphenyl)-5-methyl-(53427-77-3)
• EPA Substance Registry System: 2(1H)-Pyridinone, 1-(4-methoxyphenyl)-5-methyl-(53427-77-3)

Safety Data

• Hazardous Substances Data: 53427-77-3(Hazardous Substances Data)

Upstream product

• 104-92-7 1-bromo-4-methoxy-benzene 
• 1003-68-5 5-methyl-2-pyridone 
• 5720-07-0 4-methoxyphenylboronic acid 
• 1003-68-5 5-methyl-pyridin-2-ol 

Downstream Products

• 1347692-55-0 1-(4-methoxyphenyl)-5-((m-tolylamino)methyl)pyridin-2(1H)-one 
• 1347692-53-8 1-(4-methoxyphenyl)-5-((o-tolylamino)methyl)pyridin-2(1H)-one 
• 1347692-52-7 1-(4-methoxyphenyl)-5-((p-tolylamino)methyl)pyridin-2(1H)-one 
• 1347692-51-6 1-(4-methoxyphenyl)-5-((phenylamino)methyl)pyridin-2(1H)-one 
• 1347692-47-0 1-(4-methoxyphenyl)-5-((4-methoxyphenylamino)methyl)pyridin-2(1H)-one 
• 1347692-45-8 5-((4-acetylphenylamino)methyl)-1-(4-methoxyphenyl)pyridin-2(1H)-one 
• 1347692-44-7 5-((4-chlorophenylamino)methyl)-1-(4-methoxyphenyl)pyridin-2(1H)-one 
• 1347692-71-0 C₁₃H₁₂BrNO₂ 
• 851518-71-3 1-(4-hydroxyphenyl)-5-methylpyridine-2(1H)-one 

Relevant articles and documents

Synthesis and anti-fibrotic effects of santamarin derivatives as cytotoxic agents against hepatic stellate cell line LX2

Liver fibrosis is a final result of extensive deposition of extracellular matrix (ECM) and starts with the activation and proliferation of hepatic stellate cells (HSCs). Our previous study showed that eudesmane sesquiterpenoid santamarin had cytotoxicity

Pirfenidone structural isosteres: Design, synthesis and spectral study

Series of 5-substituted arylpyridin-2(1 H )-ones and arylpyrimidin-4(3 H )-ones were designed and synthesized based on pirfenidone, a compound which shows promising therapeutic effects for treatment of fibrosis. The compounds 1a - c , 2a - c and 3a - c were obtained under mild conditions by arylation of the appropriate heterocyclic amines with arylboronic acids under Chan-Lam- Evans conditions. The synthesis of the useful synthon N -(4-methoxyphenyl)-5-(4,4,5,5- tetramethyl-1,3,2-dioxaborolan- 2-yl)-(1 H )-pyridin-2-one ( 4 ) is also reported. All compounds were characterized by spectral and elemental analysis and structural elucidation by 1 H and 13 C NMR is discussed herein.

THE DERIVATIVES OF PYRIDONE AND THE USE OF THEM

The present invention provides N-substituted-2(1H) pyridones or the pharmaceutical acceptable salts thereof, and the pharmaceutical preparations containing the compounds. The compounds of the present invention can be used to treat various fibrotic diseases effectively, e.g., hepatic fibrosis.