53446-63-2

Basic information

• Product Name: 2-isopropylindan-1-one
• Synonyms: 2-isopropylindan-1-one;2,3-Dihydro-2-(1-methylethyl)-1H-inden-1-one;2-Isopropyl-2,3-dihydro-1H-indene-1-one;1H-Inden-1-one, 2,3-dihydro-2-(1-methylethyl)-;2-Isopropyl-1-indanone;Einecs 258-558-8
• CAS NO: 53446-63-2
• Molecular Formula: C₁₂H₁₄O
• Molecular Weight: 174.23896
• EINECS: 258-558-8
• Mol File: 53446-63-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 265.7°Cat760mmHg
• Flash Point: 107.7°C
• Appearance: /
• Density: 1.042g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 2-isopropylindan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-isopropylindan-1-one(53446-63-2)
• EPA Substance Registry System: 2-isopropylindan-1-one(53446-63-2)

Safety Data

• Hazardous Substances Data: 53446-63-2(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H14O/c1-8(2)11-7-9-5-3-4-6-10(9)12(11)13/h3-6,8,11H,7H2,1-2H3

Upstream product

• 1174039-85-0 2-isopropyl-1H-inden-1-yl acetate 
• 75-30-9 2-iodo-propane 
• 83-33-0 inden-1-one 
• 799804-39-0 2-hydroxy-3-methyl-1-(2-methylphenyl)-1-butanone 
• 529-20-4 2-methylphenyl aldehyde 
• 82128-96-9 2-trimethylsilyloxy-2-(2-methylphenyl)acetonitrile 
• 799804-29-8 3-methyl-1-(2-methylphenyl)-2-mesyloxy-1-butanone 
• 1579-14-2 2-chloroindanone 
• 1068-55-9 isopropylmagnesium chloride 
• 65869-94-5 2-benzyl-3-methyl-butyryl chloride 
• 5706-00-3 2-isopropylidene-1-indanone 

Downstream Products

• 401916-92-5 2-isopropyl-1-methyl-2,3-dihydro-1H-indene 
• 131704-07-9 cis-2,3-dihydro-2-(1-methylethyl)-1-(2-methoxyphenoxy)indene 
• 131704-07-9 trans-2,3-dihydro-2-(1-methylethyl)-1-(2-methoxyphenoxy)indene 

Relevant articles and documents

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Design, synthesis and evaluation of indene derivatives as retinoic acid receptor α agonists

A series of novel indene-derived retinoic acid receptor α (RARα) agonists have been designed and synthesized. The use of receptor binding, cell proliferation and cell differentiation assays demonstrated that most of these compounds exhibited moderate RARα binding activity and potent antiproliferative activity. In particular, 4-((3-isopropoxy-2,3-dihydro-1H-inden-5-yl)-carbamoyl) benzoic acid (36d), which showed a moderate binding affinity, exhibited a great potential to induce the differentiation of NB4 cells (68.88% at 5 μM). Importantly, our work established indene as a promising skeleton for the development of novel RARα agonists.

Synthesis of Chiral 3-Alkyl-3,4-dihydroisocoumarins by dynamic kinetic resolutions catalyzed by a Baeyer-Villiger Monooxygenase

"Chemical Equation Presented" Baeyer-Villiger monooxygenases have been tested, in the oxidation of racemic benzofused ketones. When employing a single mutant of phenylacetone monooxygenase (M.446G PAMO) under the proper reaction conditions, it was possible to achieve 3-substituted 3,4-dihydroisocoumarins with, high yields and optical purities through regioselective dynamic kinetic resolution processes.