5345-09-5Relevant academic research and scientific papers
A ortho-nitro phenol and its derivative synthesis method (by machine translation)
-
, (2017/08/23)
The invention relates to a method for the synthesis of organic compounds, in the existing technology of O-nitrophenol strong acid used in the synthesis process of the serious problem of environmental pollution and the synthesis step longer more complicated problem, the invention provides a ortho-nitro phenol and synthetic method of derivative thereof, proceeding by the phenol compound, synthesis of 2 - (phenoxy) pyridine, the obtained product, catalyst, tert-butyl nitrite, organic solvent and adding sealing in the pressure containers, in oil bath heating 50 - 100 °C, reaction 10 - 30 hours, to obtain 2 - (2 - nitrobenzene) ethoxy pyridine; re-processing by the ortho-nitro phenol and its derivatives; the method is simple, high-efficiency. (by machine translation)
An ortho-nitro phenol synthetic method of compound
-
, (2016/10/10)
The invention relates to a synthesis method of o-nitrophenol compounds, solving the problems that production hazards are easily caused due to the release of a large deal of heat during the synthesis of o-nitrophenol and the severe environment pollution caused due to the generation of a large deal of waste gas and acid in the process in the prior art. The invention provides the synthesis method of the o-nitrophenol compounds, which comprises the steps: synthesizing 2-(phenoxy)pyridine from phenol compounds; and then sequentially adding 2-(phenoxy)pyridine and a catalyst, a nitrating reagent, an oxidant and an organic solvent into a sealed pressure container, heating and reacting for 10-50 hours in an oil bath of which the temperature is 80 DEG C-130 DEG C to obtain 2-(2-nitrophenyl)oxy pyridine; and finally treating to obtain o-nitrophenol. The synthesis method is simple, convenient and efficient.
ONE POT PROCESS FOR THE CONVERSION OF AROYL CHLORIDES TO ACYL THIOUREAS
-
Page/Page column 8; 13, (2014/06/24)
The present invention disclose an improved one pot process for synthesis of acyl thioureas of formula (I), with yield greater than 80%, from aroyl chlorides of formula (I) wherein, R' is an aryl or a heteroarylene group substituted with one or more groups selected from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino, carboxyl, ester, halogenated hydrocarbon or an aryl or heteroaryl; R" and R"' are selected independently from hydrogen, alkyl, alkylene, alkynyl, alkoxy, alkenyloxy, halo, hydroxyl, nitro, amino or halogenated hydrocarbon.
Palladium-catalyzed aromatic C-H bond nitration using removable directing groups: Regiospecific synthesis of substituted o -nitrophenols from related phenols
Zhang, Wei,Zhang, Jian,Ren, Shaobo,Liu, Yunkui
, p. 11508 - 11516 (2015/01/09)
A general and regiospecific transformation of substituted phenols into the related o-nitrophenols has been achieved via a three-step process involving the palladium-catalyzed chelation-assisted ortho-C-H bond nitration as the key step. In the process, 2-pyridinyloxy groups act as removable directing groups for the palladium-catalyzed ortho-nitration of substituted 2-phenoxypridines, and they can be readily removed in the subsequent conversion of the resulting 2-(2-nitrophenoxy)pyridines into 2-nitrophenols.
Nitration of substituted phenols by different efficient heterogeneous systems
Habibi, Davood,Zolfigol, Mohammad Ali,Shiri, Morteza,Sedaghat, Abdolmajid
, p. 93 - 96 (2007/10/03)
Nitration of substituted phenols were carried out by the mixture of sodium nitrite and wet SiO2 (50% w/w) in the presence of four different efficient heterogeneous systems: 1) oxalic acid dihydrate (I), 2) sodium hydrogen sulphate (II), 3) aluminum hydrogen sulphate (III) and 4) silica sulphuric acid (IV) in CH2Cl2 at room temperature and high yields. Optimum conditions for theses systems and the regioselectivities of the reactions are reported.
FORMATION OF DIENONES ON THE REACTION OF CRESOLS, XYLENOLS, AND 2-NAPHTHOL WITH NITROGEN DIOXIDE: OBSERVATION OF KETO TAUTOMERS OF NITROPHENOLS
Fischer, Alfred,Mathivanan, N.
, p. 1869 - 1872 (2007/10/02)
Reaction of o- and p-cresol, the xylenols, and 2-naphthol with nitrogen dioxide gives nitrocyclohexadienones and nitrophenols.Secondary nitrodienones, the keto tautomers of the nitrophenols, have been observed in several cases and are intermediates in the formation of the nitrophenols.
Nitroacetylene Equivalents. Preparation and Cycloadditions of 2-Phenylsulphinyl-1-nitroalkenes
Jung, Michael E.,Grove, David D.
, p. 753 - 755 (2007/10/02)
β-Phenylsulphinyl-nitro-alkenes (7) are readily prepared from acyl imidazoles and react as nitroacetylene equivalents in Diels-Alder reactions to give good yields of cycloadducts and their further products.
NITRATION OF PHENOLS WITH NITRATES IN A TWO-PHASE SYSTEM
Gaude, D.,Goaller, R. Le,Pierre, J. L.
, p. 63 - 68 (2007/10/02)
Phenols are easily nitrated at room temperature, with good selectivity, by dilute nitric acid or metallic nitrates, in an acidic two-phase system, even without phase transfert catalyst.The results, in these experimental conditions, suggest an electron transfer mechanism for this reaction.
255. Construction of Highly Substituted Nitroaromatic Systems by Cyclocondensation. Part II. Conversion of 4-Nitr-3-oxobutyrate to 3-Nitrosalicylates
Duthaler, Rudolf O.
, p. 2543 - 2563 (2007/10/02)
The base-catalyzed reaction of 4-nitro-3-oxobutyrate (6) with acetylacetone (8), formylacetone (13), formylcyclohexanone (31), 2,4-dioxopentanoates 39 and 40, and 2,4,6-heptanetrione (2) affords substituted 3-nitrosalicylates, products of a double aldol condensation.With unsymmetrical dicarbonyl compounds both regioisomers are formed.High selectivity was found in the case of β-keto-aldehydes 13 and 31 with preferred addition of the NO2-substituted carbon to the aldehyde carbonyl.The major products of these cyclocondensations, which are isolated in yields ranging from 20 percent to 80 percent, are all new compounds.Less successful are the conversions with β-alkoxy- and β-chloro-vinyl ketones (23, 25, and 26), and with alkinone 24, where the condensation products are formed in very low yield.
