53451-22-2Relevant academic research and scientific papers
Novel routes to indoles, indolines, quinolines and tetrahydroquinolines from N-(cyclohexylidene)amines
De Kimpe, Norbert,Keppens, Marian
, p. 3705 - 3718 (1996)
Cyclohexanones have been converted into a variety of bicyclic azaheterocycles of different oxidation level via a sequence of reactions involving (a) imination, (b) α-alkylation with N,N-disilyl-protected ω-bromoamines, (c) transimination, (d) α-chlorination of the resulting bicyclic imines and (e) dehydrochlorination and/or dehydrogenation. Appropriate choice of the reaction conditions selectively led to reactions to indoles, 7-chloroindoles, 7-chloroindolines, 4,5,6,7-tetrahydroindoles, 8-chloro-1,2,3,4-tetrahydroquinolines, 8-chloroquinolines or quinolines.
Determination of the conformations and relative configurations of exocyclic amines
Montalvo-gonzlez, J. Ascencin,Iniestra-galindo, Maria Guadalupe,Ariza-castolo, Armando
body text, p. 938 - 944 (2011/07/30)
The conformations and relative configurations of 20 amines, classified according to the following labeling scheme, were analyzed. Series a comprised compounds derived from N-(1-phenylethyl)cyclohexanamine, b comprised derivatives of N-[1-(naphthalen-2-yl)ethyl]cyclohexanamine, c comprised derivatives of N-(diphenylmethyl)cyclohexanamine, and d comprised derivatives of N-(propan-2-yl)cyclohexanamine. The compounds were labeled as follows: 1 indicates cyclohexanamine, 2 indicates 2-methylcyclohexanamines, 3 indicates 3-methylcyclohexanamines, 4 indicates 4-methylcyclohexanamines, and 5 indicates 4-tert-butylcyclohexanamines. These compounds were prepared without the use of stereoselective induction and, therefore, all expected stereoisomers were observed. Structural assignments were established by 1H, 13C, and 15N NMR.
7-Methyl-1-isopropyl-4-phenyl-5,6,7,8-tetrahydro-2(1H)-quinazolinone
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, (2008/06/13)
Compounds of the formula I: SPC1 wherein R° is lower alkyl, n is 0, 1 or 2, R is lower alkyl, R' is a radical of the formula SPC2 In which Y and Y' are the same or different and represent hydrogen, lower alkyl, lower alkoxy, halo of atomic weight of 19 to 36 or one of Y and Y' is trifluoromethyl while the other is hydrogen, or a radical of the formula SPC3 In which Y" is hydrogen, fluorine, chlorine or alkyl of 1 to 3 carbon atoms, Are prepared by cyclizing a compound of formula II SPC4 in which R, R', R° and n are as defined above, with phosgene, or, Where R is not a tertiary alkyl group in which the tertiary carbon atom is directly attached to the ring nitrogen atom, with a C1 -C2 alkyl chlorocarbonate or 1,1'carbonyldiimidazole. The compounds of formula I possess pharmaceutical activity in animals.
