53460-45-0

Basic information

• Product Name: 2,3-dioxo-N-phenyl-1-indolinecarboxamide
• Synonyms: 2,3-dioxo-N-phenyl-1-indolinecarboxamide
• CAS NO: 53460-45-0
• Molecular Weight: 266.256
• Mol File: 53460-45-0.mol

Chemical Properties

• CAS DataBase Reference: 2,3-dioxo-N-phenyl-1-indolinecarboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-dioxo-N-phenyl-1-indolinecarboxamide(53460-45-0)
• EPA Substance Registry System: 2,3-dioxo-N-phenyl-1-indolinecarboxamide(53460-45-0)

Safety Data

• Hazardous Substances Data: 53460-45-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-dioxo-N-phenyl-1-indolinecarboxamide is used as a pharmaceutical compound for its potential applications in the development of drugs for various medical conditions. Its unique chemical structure and properties make it an interesting molecule for further study and exploration in drug discovery and development processes.
Used in Drug Discovery and Development:
2,3-dioxo-N-phenyl-1-indolinecarboxamide is utilized as a key molecule in drug discovery and development due to its potential to be modified and optimized for specific therapeutic targets. Its chemical properties allow for the design of novel drug candidates that can address unmet medical needs and improve patient outcomes.

Upstream product

• 62-53-3 aniline 
• 42366-35-8 hydroxyimino-N-phenylacetamide 
• 91-56-5 indole-2,3-dione 
• 103-71-9 phenyl isocyanate 

Downstream Products

• 91-56-5 indole-2,3-dione 
• 103-71-9 phenyl isocyanate 
• 107583-03-9 3'-Phenylspiro-2,2',5(3'H)-trione 
• 1279575-32-4 (1S,4R,5S)-dimethyl-2'-oxo-4-phenyl-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-43-7 (1S,4R,5S)-dimethyl-4-(4-bromophenyl)-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-45-9 (1S,4R,5S)-dimethyl-4-(4-chlorophenyl)-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-46-0 (1S,4R,5S)-dimethyl-4-(3-chlorophenyl)-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-49-3 (1S,4R,5S)-dimethyl-4-(4-nitrophenyl)-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-50-6 (1S,4R,5S)-dimethyl-4-(4-cyanophenyl)-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-52-8 (1S,4R,5S)-dimethyl-4-(4-methoxyphenyl)-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-53-9 (1S,4S,5S)-dimethyl-2'-oxo-1'-(phenylcarbamoyl)-4-(thiophen-2-yl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 
• 1279575-55-1 (1S,4S,5S)-dimethyl4-methyl-2'-oxo-1'-(phenylcarbamoyl)spiro[cyclopent[2]ene-1,3'-indoline]-3,5-dicarboxylate 

Relevant articles and documents

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Biological activities and quantitative structure-activity relationships of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones as aldose reductase inhibitors

A series of spiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-triones were prepared and tested for aldose reductase inhibitory activity. The 6'- halogenated derivatives were found to be highly potent in vitro inhibitors of male rabbit lens aldose reductase and in vivo inhibitors of polyol accumulation in the sciatic nerves of galactosemic rats. Of these, (4R)-6'- chloro-3'-methylspiro[imidazolidine-4,4'(1'H)-quinazoline]-2,2',5(3'H)-trione (67) showed the most potent in vitro and in vivo activities. An oral dose of 3 g/kg of compound 67 caused neither death nor behavioral abnormality in the preliminary acute toxicity study using mice and rats. Compound 67 was selected as a candidate for further evaluation. The quantitative structure- activity relationships in this series are also discussed.