534605-78-2

Downstream Products

• 1167442-16-1 C₃₃H₂₉N₅O₈ 
• 867064-26-4 (9S)-9-{2-[(R-2-tert-butoxycarbonylamino-2-ethoxycarbonyl)ethanesulfanyl]ethoxycarbonyloxy}-9-ethyl-1-pentyl-1H,12H-pyrano[3'',4'':6',7']indolizino[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione 
• 867064-24-2 (9S)-9-{2-[(R-2-tert-butoxycarbonylamino-2-methoxycarbonyl)ethanesulfanyl]ethoxycarbonyloxy}-9-ethyl-1-pentyl-1H,12H-pyrano[3'',4'':6',7']indolizino[1',2':6,5]pyrido[4,3,2-de]quinazoline-10,13(9H,15H)-dione 

Relevant academic research and scientific papers

Synthesis and biological activities of a pH-dependently activated water-soluble prodrug of a novel hexacyclic camptothecin analog

CH0793076 (1) is a novel hexacyclic camptothecin analog showing potent antitumor activity in various human caner xenograft models. To improve the water solubility of 1, water-soluble prodrugs were designed to generate an active drug 1 nonenzymatically, th