5347-68-2

Basic information

• Product Name: 2,3-DIMETHYLPIPERIDINE
• Synonyms: 2,3-DIMETHYLPIPERIDINE;ASINEX-REAG BAS 07760095;2,3-dimethylpiperidine hydrobromide;Nonafin (free base);Piperidine, 2,3-dimethyl-;Piperidine, 2,3-dimethyl- (9CI)
• CAS NO: 5347-68-2
• Molecular Formula: C₇H₁₅N
• Molecular Weight: 113.2
• Product Categories: Piperidine
• Mol File: 5347-68-2.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 140.3°Cat760mmHg
• Flash Point: 28°C
• Appearance: /
• Density: 0.794g/cm³
• Vapor Pressure: 6.17mmHg at 25°C
• Refractive Index: 1.416
• PKA: 10.67±0.10(Predicted)
• CAS DataBase Reference: 2,3-DIMETHYLPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIMETHYLPIPERIDINE(5347-68-2)
• EPA Substance Registry System: 2,3-DIMETHYLPIPERIDINE(5347-68-2)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 5347-68-2(Hazardous Substances Data)

Usage

Uses

2,3-Dimethylpiperidine is involved in the synthesis of novel 3-bromo-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxylic acid amide compounds.

InChI:InChI=1/C7H15N/c1-6-4-3-5-8-7(6)2/h6-8H,3-5H2,1-2H3

Upstream product

• 412320-62-8 5,6-dimethyl-1,2,3,4-tetrahydro-pyridine 
• 10413-01-1 4-methyl-5-oxo-hexanenitrile 
• 7647-01-0 hydrogenchloride 
• 583-61-9 2,3-Lutidine 

Downstream Products

• 1366233-48-8 N-(4-methylphenyl)-4-[(2,3-methyl-1-piperidinyl)carbonyl]-1,3-thiazol-2-amine 
• 946086-44-8 2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanyl-2,3-dimethylpiperidin-1-yl ketone 

Relevant articles and documents

Borane-Catalyzed Reduction of Pyridines via a Hydroboration/Hydrogenation Cascade

We have developed a method for a B(C6F5)3-catalyzed hydroboration/hydrogenation cascade reduction of pyridines. The method was particularly effective for 2,3-disubstituted pyridines, which generated piperidines in high yields with high cis selectivity. Mechanistic studies indicated that the pyridine substrates and the piperidine products sequentially acted as bases in cooperation with B(C6F5)3to split H2. The broad functional group tolerance of the method allowed its use for the synthesis of some biologically active molecules.

Novel 3-phenylprop-2-ynylamines as inhibitors of mammalian squalene epoxidase.

The synthesis of a novel series of 3-phenylprop-2-ynylamines as selective mammalian squalene epoxidase inhibitors is described. Structure activity relationship studies led to the discovery of compound 19, 1-[3-(3,5-dichlorophenyl)-prop-2-ynyl]-3- methylpiperidine hydrochloride with an IC50 of 2.8 +/- 0.6 microM against rat liver squalene epoxidase. Against 23 strains of fungal squalene epoxidase compound 19 was found to be inactive.