53472-18-7

Basic information

• Product Name: 5-BROMO-QUINOLIN-8-YLAMINE
• Synonyms: ART-CHEM-BB B015996;AKOS B015996;AKOS MSC-0726;5-BROMOQUINOLIN-8-AMINE;5-BROMO-QUINOLIN-8-YLAMINE;5-BROMO-8-AMINOQUINOLINE;5-BROMO-8-QUINOLINAMINE;TIMTEC-BB SBB001595
• CAS NO: 53472-18-7
• Molecular Formula: C₉H₇BrN₂
• Molecular Weight: 223.07
• Product Categories: Quinoline&Isoquinoline
• Mol File: 53472-18-7.mol
• Article Data: 15

Chemical Properties

• Melting Point: 109-110 °C
• Boiling Point: 353.3°Cat760mmHg
• Flash Point: 167.5°C
• Appearance: /
• Density: 1.649g/cm³
• Vapor Pressure: 3.61E-05mmHg at 25°C
• Refractive Index: 1.732
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.02±0.12(Predicted)
• CAS DataBase Reference: 5-BROMO-QUINOLIN-8-YLAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-QUINOLIN-8-YLAMINE(53472-18-7)
• EPA Substance Registry System: 5-BROMO-QUINOLIN-8-YLAMINE(53472-18-7)

Safety Data

• Hazardous Substances Data: 53472-18-7(Hazardous Substances Data)

Usage

General Description

5-Bromo-Quinolin-8-Ylamine is a chemical compound that belongs to the class of organic compounds known as quinolines and derivatives. These are compounds containing a quinoline moiety, a two-ring aromatic system derived from benzene and pyridine through the fusion of an imidazole ring at the benzene moiety. It is also identified as an aromatic amine, which consists of an amine attached to an aromatic hydrocarbon. 5-Bromo-Quinolin-8-Ylamine is used mainly in chemical synthesis and pharmaceutical research mostly due to its distinctive structure, displaying properties of both amine and aromatic groups. While little information is available about its direct applications, typically molecules like this are used as intermediate compounds for creating new, more complex molecules.

InChI:InChI=1/C9H7BrN2/c10-7-3-4-8(11)9-6(7)2-1-5-12-9/h1-5H,11H2

Upstream product

• 176967-80-9 5-bromo-8-nitroquinoline 
• 33757-48-1 N-quinolin-8-yl-benzamide 
• 170891-76-6 α,α,α-trimethyl-N-(quinolin-8-yl)acetamide 
• 578-66-5 8-amino quinoline 

Downstream Products

• 1215767-84-2 5-bromo-7-chloroquinoline 
• 40000-20-2 5-bromo-1,10-phenanthroline 
• 16204-88-9 N-(5-bromoquinolin-8-yl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Merging Photoredox Catalysis with Iron(III) Catalysis: C5-H Bromination and Iodination of 8-Aminoquinoline Amides in Water

A simple and efficient protocol for the iron(III)-catalyzed C5 halogenation of 8-aminoquinoline with potassium halides via a photoredox process was developed, affording desired products in good to excellent yields. This reaction features its mild and gree

Visible light-induced mono-bromination of arenes with BrCCl3

A highly efficient and regioselective bromination of electron-rich arenes and heteroarenes using commercially available BrCCl3as a “Br” source has been developed. The reaction was performed in air under mild conditions with photocatalyst Ru(bpy)3Cl2·6H2O, avoiding the usage of strong acids and strong oxidants. Mono-brominated products were obtained with medium to excellent yields (up to 94%). This strategy has shown good compatibility and highpara-selectivity, which will facilitate the complicated synthesis.

New compound used as rearranged during transfection kinase inhibitor

The present invention relates to a compound, a pharmaceutical composition containing the compound, a preparation method of the compounds, and application of the same as a rearranged during transfection (RET) kinase inhibitor. The compound is a compound shown as formula (I), or a pharmaceutically acceptable salt, a prodrug, a solvent compound, a polymorph, an isomer and a stable isotope derivativethereof. The present invention also relates to the application of the compounds to treatment or prevention of RET kinase mediated related diseases like tumors and a method of using the compounds for the treatment of the diseases.