53473-35-1

Upstream product

• 108-24-7 acetic anhydride 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 3470-50-6 6-Hydroxy-1-tetralone 
• 89228-44-4 5,6,7,8-tetrahydronaphthalen-2-yl acetate 
• 75-36-5 acetyl chloride 

Downstream Products

• 150712-57-5 5-methoxynaphthalen-2-ol 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 4985-08-4 Δ^{1,3,5(10),9(11)}-8,14-seco-D-homo-oestratetraen-3-ol-14,17a-dion 
• 16711-75-4 1,2,3,4-Tetrahydro-6-acetoxy-1-(p-hydroxy-benzyl)-naphthalin 

Relevant academic research and scientific papers

Intramolecular Büchner reaction and oxidative aromatization with SeO2 or O2

Intramolecular Büchner reaction of 1-diazo-5-phenylpentan-2-ones followed by oxidation with SeO2 or O2 in the presence of silica gel regioselectively gave 8-formyl-1-tetralones or one-carbon-lacking 1-tetralones, respectively.

Deleterious effect of 7-methyl group on glycosylation of 2-naphthols

C-Glycosylations of several 2-naphthols with different glycosyl donors have been investigated in the pursuit of the total synthesis of mayamycin (1). While glycosylations of the parent 2-naphthol are readily achievable, those of 5-methoxy-7-methyl-2-napht

Asymmetric catalytic aziridination of dihydronaphthalenes for the preparation of substituted 2-aminotetralins

An enantioselective synthesis of substituted 2-aminotetralins from dihydronaphthalenes in four steps is described. The key step is the Jacobsen's (diimine)copper-catalyzed asymmetric aziridination of dihydronaphthalenes to the respective aziridines in 33-82% yields and 60-87% enantiomeric excess. The enantioselectivity and the yield were dependent on the properties of the nitrene precursor. pTsNIPh appeared in general to give better results than pNsNIPh. Aziridines were ring-opened in the benzylic position by catalytic hydrogenolysis in quantitative yields, and deprotected in two steps to the respective 2-aminotetralins in 66-85% yields. The synthesis of (S)-2-aminotetralin (>98% ee) and (S)-2-amino-7-methoxytetralin (56% ee) were accomplished in 30 and 52% overall yields, respectively.

Regioselective hydroperoxygenation of aralkanes and α,β- unsaturated carbonyl compounds catalyzed by N-hydroxyphthalimide and 2,2′-azobis (4-methoxy-2,4-dimethylvaleronitrile)

Aerobic oxidation of aralkanes and α,β-unsaturated carbonyl compounds in the presence of a catalytic amount of N-hydroxyphthalimide (NHPI) and 2,2′-Azobis(4-methoxy-2,4-dimethylvaleronitrile) (V-70) under 1 atmos. of oxygen at 30°C gave α-hydroperoxyaralkanes and γ-hydroperoxy-α,β-unsaturated carbonyl compounds, respectively. Copyright Taylor & Francis, Inc.

2-Aminothiazoles: A new class of agonist allosteric enhancers of A1 adenosine receptors

This report describes the synthesis and structure-activity relationships of a new class of A1 adenosine receptor agonist allosteric enhancers, 2-aminothiazolium salts. The EC50 of compounds 6a, 6b, 7, and 8 were 0.3, 4.5, 3.8, and 1.2 μM, substantially lower than that of the 'Gold Standard' 2-amino-3-benzoyl thiophene (PD 81,723), which has an EC50 of 38 μM.