53475-39-1

Upstream product

• 63913-42-8 (3E)-4-morpholin-4-yl-pent-3-en-2-one 
• 614-16-4 Benzoylacetonitrile 
• 1118-66-7 4-amino-3-penten-2-one 

Downstream Products

• 143572-51-4 3-Benzoyl-1-ethyl-4,6-dimethyl-1H-pyridin-2-one 

Relevant academic research and scientific papers

Pyridine and pyrimidine ring syntheses from 4-(4-morpholino)-3-pentenone and from ethyl 3-(4-morpholino)-2-butenoate

3-Substituted 2(1H)-pyridones are produced from reaction of 4-(4- morpholino)-3-pentenone 1 with each of the following carbon acids: cyanoacetamide, malononitrile, cyanothioacetamide, acetylacetamide, benzoyl- acetonitrile. Reaction of ethyl 3-(4-morpholino)-2-butenoate 2 with cyanoacetamide gives the corresponding hydroxypyridone. Pyrimidines are formed by reaction of 1 and of 2 with benzamidine and with S-benzylthiourea; in the last case, the eliminated morpholine displaces the benzylthio group to give the final product.

The Reaction of β-Aminoenones with Substituted Acetonitriles. Regiospecific Synthesis of 2(1H)-Pyridones

Unsymmetrically substituted β-aminoenones react with malononitrile, cyanomethylphenylsulfone, benzoylacetonitrile and ethyl cyanoacetate, in very mild conditions, to yield regiospecifically 3-functionalized 2(1H)-pyridones in high yields.