53475-39-1Relevant articles and documents
Pyridine and pyrimidine ring syntheses from 4-(4-morpholino)-3-pentenone and from ethyl 3-(4-morpholino)-2-butenoate
Ratemi,Namdev,Gibson
, p. 1513 - 1516 (1993)
3-Substituted 2(1H)-pyridones are produced from reaction of 4-(4- morpholino)-3-pentenone 1 with each of the following carbon acids: cyanoacetamide, malononitrile, cyanothioacetamide, acetylacetamide, benzoyl- acetonitrile. Reaction of ethyl 3-(4-morpholino)-2-butenoate 2 with cyanoacetamide gives the corresponding hydroxypyridone. Pyrimidines are formed by reaction of 1 and of 2 with benzamidine and with S-benzylthiourea; in the last case, the eliminated morpholine displaces the benzylthio group to give the final product.