53485-05-5

Basic information

• Product Name: 1,3-PropanediaMine, N,N-bis(1-Methylethyl)-
• Synonyms: 1,3-PropanediaMine, N,N-bis(1-Methylethyl)-
• CAS NO: 53485-05-5
• Molecular Formula: C₉H₂₂N₂
• Molecular Weight: 158.28438
• Mol File: 53485-05-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-PropanediaMine, N,N-bis(1-Methylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-PropanediaMine, N,N-bis(1-Methylethyl)-(53485-05-5)
• EPA Substance Registry System: 1,3-PropanediaMine, N,N-bis(1-Methylethyl)-(53485-05-5)

Safety Data

• Hazardous Substances Data: 53485-05-5(Hazardous Substances Data)

Usage

General Description

1,3-Propanediamine, N,N-bis(1-methylethyl)-, also known as N,N'-diisopropylethylenediamine, is a chemical compound used as a catalyst and a reagent in organic synthesis. It is a clear, colorless liquid with a strong ammonia-like odor. 1,3-Propanediamine, N,N-bis(1-methylethyl)- is commonly used in the production of polyurethane foams and elastomers, as well as in the synthesis of pharmaceuticals and agrochemicals. It is a versatile reagent that is often used in the formation of amide and carbamate linkages, and as a strong base in various reactions. However, it is important to handle this chemical with caution, as it can cause skin and eye irritation, and may be harmful if swallowed or inhaled.

Upstream product

• 108-18-9 diisopropylamine 
• 107-02-8 acrolein 
• 112359-48-5 N-(2-cyanoethyl)-N,N-diisopropylamine 

Downstream Products

• 68497-64-3 N-[3-[bis(1-methylethyl)amino]propyl]-2-oxo-4-phenyl-1-pyrrolidineacetamide 
• 6738-00-7 <4-Chlorphenoxy>-essigsaeure-<3-diisopropylaminopropylamid> 

Relevant articles and documents

Preparing method for N,N-diisopropyl-1,3-propane diamine

The invention discloses a preparing method for N,N-diisopropyl-1,3-propane diamine. Acrylonitrile and diisopropylamine serve as raw materials, a reflux reaction is conducted at the temperature of 80 DEG C to 84 DEG C in the inert environment under an effect of a micro water catalyst, and N,N-diisopropyl propionitrile is prepared; in an absolute ethyl alcohol solvent system, sodium borohydride serves as a reducing agent, a reduction reaction is conducted on the N,N-diisopropyl propionitrile, and the N,N-diisopropyl-1,3-propane diamine is prepared. According to the preparing method, the raw materials are easy to obtain, a preparing technology is simple, reaction conditions are mild, and the production cost is low.

Salicylamide inhibitors of influenza virus fusion

Structural variation of the quinolizidine heterocycle of the influenza fusion inhibitor BMY-27709 was examined by several topological dissections in order to illuminate the critical features of the ring system. This exercise resulted in the identification of a series of synthetically more accessible decahydroquinolines that retained the structural elements of BMY-27709 important for antiviral activity. The 2-methyl-cis-decahydroquinoline 6f was the most potent influenza inhibitor identified that demonstrated an EC50 of 90 ng/mL in a plaque reduction assay. (C) 2000 Elsevier Science Ltd. All rights reserved.