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Glybuthiazol is a chemical compound belonging to the thiazole class of organic compounds, known for its potential as an antidiabetic, anti-inflammatory agent, and its investigational role in treating obesity and metabolic syndrome. It exhibits insulin-sensitizing and glucose-lowering effects, with possible antioxidant and neuroprotective properties, although further research is required to fully elucidate its therapeutic applications and potential risks.

535-65-9

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535-65-9 Usage

Uses

Used in Pharmaceutical Industry:
Glybuthiazol is used as an antidiabetic agent for its insulin-sensitizing and glucose-lowering effects, which can help manage blood sugar levels in individuals with diabetes.
Used in Anti-inflammatory Applications:
Glybuthiazol is used as an anti-inflammatory agent, potentially beneficial in reducing inflammation associated with various conditions.
Used in Obesity and Metabolic Syndrome Treatment:
Glybuthiazol is used as a therapeutic agent for treating obesity and metabolic syndrome due to its potential to address underlying metabolic issues.
Used in Antioxidant and Neuroprotective Therapies:
Glybuthiazol is used as an antioxidant and neuroprotective agent, suggesting its potential to protect against oxidative stress and neurodegenerative conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 535-65-9 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 5 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 535-65:
(5*5)+(4*3)+(3*5)+(2*6)+(1*5)=69
69 % 10 = 9
So 535-65-9 is a valid CAS Registry Number.
InChI:InChI=1/C12H16N4O2S2/c1-12(2,3)10-14-15-11(19-10)16-20(17,18)9-6-4-8(13)5-7-9/h4-7H,13H2,1-3H3,(H,15,16)

535-65-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-amino-N-(5-tert-butyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide

1.2 Other means of identification

Product number -
Other names glybuthiazol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:535-65-9 SDS

535-65-9Relevant academic research and scientific papers

Development of sulfonamide AKT PH domain inhibitors

Ahad, Ali Md.,Zuohe, Song,Du-Cuny, Lei,Moses, Sylvestor A.,Zhou, Li Li,Zhang, Shuxing,Powis, Garth,Meuillet, Emmanuelle J.,Mash, Eugene A.

, p. 2046 - 2054 (2011/05/05)

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the pleckstrin homology (PH) domain of AKT and induced apoptosis when present at low micromolar concentrations. To examine the effects of structural modification, a set of sulfonamides related to the lead compound was designed, synthesized, and tested for binding to the expressed PH domain of AKT using a surface plasmon resonance-based competitive binding assay. Cellular activity was determined by means of an assay for pAKT production and a cell killing assay using BxPC-3 cells. The most active compounds in the set are lipophilic and possess an aliphatic chain of the proper length. Results were interpreted with the aid of computational modeling. This paper represents the first structure-activity relationship (SAR) study of a large family of AKT PH domain inhibitors. Information obtained will be used in the design of the next generation of inhibitors of AKT PH domain function.

SMALL MOLECULE INHIBITORS OF THE PLECKSTRIN HOMOLOGY DOMAIN AND METHODS FOR USING SAME

-

, (2009/12/02)

Pleckstrin homology domain binding compounds, pharmaceutical compositions including such compounds, and methods for their use are described herein.

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