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535-89-7

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535-89-7 Usage

Chemical Properties

Crimidine is a brown, waxy solid

Uses

Different sources of media describe the Uses of 535-89-7 differently. You can refer to the following data:
1. Rodenticide.
2. Crimidine can be used for pesticidal utility.

General Description

Brown waxy solid or colorless crystals. Used as a rodenticide. Not registered as a pesticide in the U.S.

Reactivity Profile

CRIMIDINE neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

Super toxic; probable oral lethal dose in humans is less than 5 mg/kg or less than 7 drops for a 70 kg (150 lb.) person. May cause serious central nervous system damage leading to convulsions.

Fire Hazard

CRIMIDINE emits highly toxic chloride fumes when heated to decomposition. Avoid acids and acid fumes. Very stable in neutral medium. Avoid decomposing heat.

Potential Exposure

Crimidine is used as a rodenticide. Not registered for use in the United States as a pesticide

Incompatibilities

Acids and acid fumes, strong bases.

Waste Disposal

In accordance with 40CFR165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local 934 Crimidine or federal environmental control agency, or by contacting your regional EPA office.

Check Digit Verification of cas no

The CAS Registry Mumber 535-89-7 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 5,3 and 5 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 535-89:
(5*5)+(4*3)+(3*5)+(2*8)+(1*9)=77
77 % 10 = 7
So 535-89-7 is a valid CAS Registry Number.
InChI:InChI=1/C7H10ClN3/c1-5-4-6(11(2)3)10-7(8)9-5/h4H,1-3H3

535-89-7SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name crimidine

1.2 Other means of identification

Product number -
Other names Crimidin

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:535-89-7 SDS

535-89-7Relevant articles and documents

Pyrimidyn-Based Dynamin Inhibitors as Novel Cytotoxic Agents

Odell, Luke R.,Chau, Ngoc,Russell, Cecilia C.,Young, Kelly A.,Gilbert, Jayne,Robinson, Phillip J.,Sakoff, Jennette A.,McCluskey, Adam

, (2021/11/16)

Five focused libraries of pyrimidine-based dynamin GTPase inhibitors, in total 69 compounds were synthesised, and their dynamin inhibition and broad-spectrum cytotoxicity examined. Dynamin plays a crucial role in mitosis, and as such inhibition of dynamin was expected to broadly correlate with the observed cytotoxicity. The pyrimidines synthesised ranged from mono-substituted to trisubstituted. The highest levels of dynamin inhibition were noted with di- and tri- substituted pyrimidines, especially those with pendent amino alkyl chains. Short chains and simple heterocyclic rings reduced dynamin activity. There were three levels of dynamin activity noted: 1–10, 10–25 and 25–60 μM. Screening of these compounds in a panel of cancer cell lines: SW480 (colon), HT29 (colon), SMA (spontaneous murine astrocytoma), MCF-7 (breast), BE2-C (glioblastoma), SJ-G2 (neuroblastoma), MIA (pancreas), A2780 (ovarian), A431 (skin), H460 (lung), U87 (glioblastoma) and DU145 (prostate) cell lines reveal a good correlation between the observed dynamin inhibition and the observed cytotoxicity. The most active analogues (31 a,b) developed returned average GI50 values of 1.0 and 0.78 μM across the twelve cell lines examined. These active analogues were: N2-(3-dimethylaminopropyl)-N4-dodecyl-6-methylpyrimidine-2,4-diamine (31 a) and N4-(3-dimethylaminopropyl)-N2-dodecyl-6-methylpyrimidine-2,4-diamine (31 b).

Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain

Odell, Luke R.,Abdel-Hamid, Mohammed K.,Hill, Timothy A.,Chau, Ngoc,Young, Kelly A.,Deane, Fiona M.,Sakoff, Jennette A.,Andersson, Sofia,Daniel, James A.,Robinson, Phillip J.,McCluskey, Adam

supporting information, p. 349 - 361 (2017/04/26)

The large GTPase dynamin mediates membrane fission during clathrin-mediated endocytosis (CME). The aminopyrimidine compounds were reported to disrupt dynamin localization to the plasma membrane via the PH domain and implicate this mechanism in the inhibition of CME. We have used a computational approach of binding site identification, docking, and interaction energy calculations to design and synthesize a new library of aminopyrimidine analogues targeting site-2 of the pleckstrin homology (PH) domain. The optimized analogues showed low micromolar inhibition against both dynamin I (IC50 = 10.6 ± 1.3 to 1.6 ± 0.3 μM) and CME (IC50(CME) = 65.9 ± 7.7 to 3.7 ± 1.1 mM), which makes this series among the more potent inhibitors of dynamin and CME yet reported. In CME and growth inhibition cell-based assays, the data obtained was consistent with dynamin inhibition. CEREP ExpresS profiling identified off-target effects at the cholecystokinin, dopamine D2, histamine H1 and H2, melanocortin, melatonin, muscarinic M1 and M3, neurokinin, opioid KOP and serotonin receptors.

Pyrimidine-based antagonists of h-MCH-R1 derived from ATC0175: In vitro profiling and in vivo evaluation

Semple, Graeme,Tran, Thuy-Anh,Kramer, Bryan,Hsu, Debbie,Han, Sangdon,Choi, Juyi,Vallar, Pureza,Casper, Martin D.,Zou, Ning,Hauser, Erin K.,Thomsen, William,Whelan, Kevin,Sengupta, Dipanjan,Morgan, Michael,Sekiguchi, Yoshinori,Kanuma, Kosuke,Chaki, Shigeyuki,Grottick, Andrew J.

supporting information; experimental part, p. 6166 - 6171 (2010/06/19)

A series of pyrimidine analogues derived from ATC0175 were potent antagonists of human MCH-R1 in vitro. Significantly improved receptor selectivity was achieved with several analogues from this series, but no improvement in brain partitioning was noted. One example from this series was shown to inhibit food intake and decrease body weight in a chronic study. However no clear correlation between the pharmacodynamic effect and the pharmacokinetic data with respect to brain concentration was discernible leading us to conclude that the observed effect was most likely not due to interaction with the MCH-R1.

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