5350-40-3

Basic information

• Product Name: 4-methyl-N-[(E)-phenylmethylidene]pyridin-2-amine
• CAS NO: 5350-40-3
• Molecular Formula: C₁₃H₁₂N₂
• Molecular Weight: 196.2478
• Mol File: 5350-40-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 363.2°C at 760 mmHg
• Flash Point: 173.4°C
• Density: 1.01g/cm³
• Vapor Pressure: 3.84E-05mmHg at 25°C
• Refractive Index: 1.568
• CAS DataBase Reference: 4-methyl-N-[(E)-phenylmethylidene]pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-N-[(E)-phenylmethylidene]pyridin-2-amine(5350-40-3)
• EPA Substance Registry System: 4-methyl-N-[(E)-phenylmethylidene]pyridin-2-amine(5350-40-3)

Safety Data

• Hazardous Substances Data: 5350-40-3(Hazardous Substances Data)

Upstream product

• 695-34-1 2-Amino-4-methylpyridine 
• 100-52-7 benzaldehyde 
• 329-89-5 6-aminonicotinic amide 

Downstream Products

• 13021-71-1 benzyl-(4-methylpyridin-2-yl)amine 
• 1228040-46-7 3-benzyl-7-methyl-2-phenylimidazo[1,2-a]pyridine 
• 300708-60-5 7-methyl-2-phenylimidazo[1,2-a]pyridine-3-carbaldehyde 
• 1314079-03-2 4-methyl-N-(1-phenylallyl)-2-aminopyridine 

Relevant articles and documents

Copper-Catalyzed Asymmetric Arylation of N-Heteroaryl Aldimines: Elementary Step of a 1,4-Insertion

Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N-azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4-insertion in the reaction pathway, a step in which an aryl-copper species adds directly across four atoms of C=N?C=N in the N-azaaryl aldimines.

A mild method for the regioselective bromination of 2-aminopyridines

An efficient and regioselective bromination of 2-aminopyridines was developed. The environmental friendly bromination occurs under mild and clean conditions using readily available 1-butylpyridinium bromide as the bromine source and hydrogen peroxide as the green oxidant.

Copper-catalyzed intramolecular dehydrogenative aminooxygenation: Direct access to formyl-substituted aromatic N-heterocycles

A direct synthesis of carbaldehydes through intramolecular dehydrogenative aminooxygenation has been developed. The process uses a catalytic amount of copper(II) in DMF or DMA under oxygen and does not require additional oxidants (see scheme). Mechanistic studies suggest that the carbonyl oxygen atom of the aldehyde is derived from oxygen through a copper-mediated oxygen activation process via a peroxy-copper(III) intermediate. Copyright